1887

Abstract

Introduction. Mycobacterium xenopi is a rare opportunistic pathogen mainly causing infections in immunocompromised human patients or those with underlying chronic structural lung disease. Cases of disease in veterinary medicine remain scarce. Few animal species, including birds, are suspected of being vectors of the disease and there has not yet been a report of clinical disease in birds. We report the first case, to our knowledge, of systemic infection in a domestic bird.

Case presentation. A female fiery-shouldered conure was submitted after death for necropsy following episodes of heavy breathing. The necropsy revealed multiple granulomatous lesions within the liver, air sacs and kidneys. Ziehl–Neelsen stains demonstrated the presence of numerous intralesional acid-fast bacilli. PCR assays and culture confirmed the presence of M. xenopi.

Conclusion. Through this case we hope to describe the characteristics of M. xenopi disease in birds and the possible close relationship between animal and human infections.

  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Loading

Article metrics loading...

/content/journal/jmmcr/10.1099/jmmcr.0.005158
2018-07-04
2024-04-18
Loading full text...

Full text loading...

/deliver/fulltext/jmmcr/5/7/jmmcr005158.html?itemId=/content/journal/jmmcr/10.1099/jmmcr.0.005158&mimeType=html&fmt=ahah

References

  1. Eisenstadt J, Hall GS. Microbiology and classification of mycobacteria. Clin Dermatol 1995; 13:197–206 [View Article][PubMed]
    [Google Scholar]
  2. Tortoli E. Microbiological features and clinical relevance of new species of the genus Mycobacterium. Clin Microbiol Rev 2014; 27:727–752 [View Article][PubMed]
    [Google Scholar]
  3. Bercovier H, Vincent V. Mycobacterial infections in domestic and wild animals due to Mycobacterium marinum, M. fortuitum, M. chelonae, M. porcinum, M. farcinogenes, M. smegmatis, M. scrofulaceum, M. xenopi, M. kansasii, M. simiae and M. genavense. Rev Sci Tech 2001; 20:265–290 [View Article][PubMed]
    [Google Scholar]
  4. Hashimoto A, Koga H, Kohno S, Miyazaki Y, Kaku M et al. Rapid detection and identification of mycobacteria by combined method of polymerase chain reaction and hybridization protection assay. J Infect 1996; 33:71–77 [View Article][PubMed]
    [Google Scholar]
  5. Cousins DV. Mycobacterium bovis infection and control in domestic livestock. Rev Sci Tech 2001; 20:71–85 [View Article][PubMed]
    [Google Scholar]
  6. Gavier-Widén D, Cooke MM, Gallagher J, Chambers MA, Gortázar C. A review of infection of wildlife hosts with Mycobacterium bovis and the diagnostic difficulties of the 'no visible lesion' presentation. N Z Vet J 2009; 57:122–131 [View Article][PubMed]
    [Google Scholar]
  7. Pollock JM, Neill SD. Mycobacterium bovis infection and tuberculosis in cattle. Vet J 2002; 163:115–127 [View Article][PubMed]
    [Google Scholar]
  8. Miller RS, Sweeney SJ. Mycobacterium bovis (bovine tuberculosis) infection in North American wildlife: current status and opportunities for mitigation of risks of further infection in wildlife populations. Epidemiol Infect 2013; 141:1357–1370 [View Article][PubMed]
    [Google Scholar]
  9. Nishi JS, Shury T, Elkin BT. Wildlife reservoirs for bovine tuberculosis (Mycobacterium bovis) in Canada: strategies for management and research. Vet Microbiol 2006; 112:325–338 [View Article][PubMed]
    [Google Scholar]
  10. Harris NB, Barletta RG. Mycobacterium avium subsp. paratuberculosis in veterinary medicine. Clin Microbiol Rev 2001; 14:489–512 [View Article][PubMed]
    [Google Scholar]
  11. Dhama K, Mahendran M, Tiwari R, Dayal Singh S, Kumar D et al. Tuberculosis in birds: insights into the Mycobacterium avium infections. Vet Med Int 2011; 2011:1–14 [View Article][PubMed]
    [Google Scholar]
  12. Al Houqani M, Jamieson F, Chedore P, Mehta M, May K et al. Isolation prevalence of pulmonary nontuberculous mycobacteria in Ontario in 2007. Can Respir J 2011; 18:19–24 [View Article][PubMed]
    [Google Scholar]
  13. Gommans EP, Even P, Linssen CF, van Dessel H, van Haren E et al. Risk factors for mortality in patients with pulmonary infections with non-tuberculous mycobacteria: a retrospective cohort study. Respir Med 2015; 109:137–145 [View Article][PubMed]
    [Google Scholar]
  14. Stout JE, Koh WJ, Yew WW. Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect Dis 2016; 45:123–134 [View Article][PubMed]
    [Google Scholar]
  15. Bluth MH, vera R, Razeq J, Kramer M, Abu-Lawi KI. Mycobacterium xenopi: evidence for increased rate of clinical isolation. Int J Biomed Sci 2009; 5:96–100[PubMed]
    [Google Scholar]
  16. Alfreijat M, Ononiwu C, Sexton C. Pott's disease: a case of Mycobacterium xenopi infection of the spine. J Community Hosp Intern Med Perspect 2012; 2: [View Article][PubMed]
    [Google Scholar]
  17. Kuntz M, Seidl M, Henneke P. Osteomyelitis because of Mycobacterium xenopi in an immunocompetent child. Pediatr Infect Dis J 2016; 35:110–113 [View Article][PubMed]
    [Google Scholar]
  18. Sánchez R, Font B, Pi J. Mycobacterium xenopi flexor tenosynovitis. J Hand Surg Eur Vol 2010; 35:516–517 [View Article][PubMed]
    [Google Scholar]
  19. Marusić A, Katalinić-Janković V, Popović-Grle S, Janković M, Mazuranić I et al. Mycobacterium xenopi pulmonary disease – epidemiology and clinical features in non-immunocompromised patients. J Infect 2009; 58:108–112 [View Article][PubMed]
    [Google Scholar]
  20. Gupta A, McBride AM, Holder KA, Heggem B, Royal AB et al. Pathology in practice. Severe pyogranulomatous pneumonia, enteritis, and lymphadenitis with numerous acid-fast bacteria (M xenopi). J Am Vet Med Assoc 2012; 240:1427–1429 [View Article][PubMed]
    [Google Scholar]
  21. Jarnagin JL, Richards WD, Muhm RL, Ellis EM. The isolation of Mycobacterium xenopi from granulomatous lesions in swine. Am Rev Respir Dis 1971; 104:763–765 [View Article][PubMed]
    [Google Scholar]
  22. Tomasovic AA, Rac R, Purcell DA. Mycobacterium xenopi in a skin lesion of a cat. Aust Vet J 1976; 52:103 [View Article][PubMed]
    [Google Scholar]
  23. Davendralingam N, Davagnanam I, Stidworthy MF, Baldrey V, Peters LM et al. Transmission of Mycobacterium xenopi to a pet albino ferret (Mustela putorius furo) from a domestic aquarium. Vet Rec 2017 [View Article][PubMed]
    [Google Scholar]
  24. Meeks C, Levy JK, Crawford PC, Farina LL, Origgi F et al. Chronic disseminated Mycobacterium xenopi infection in a cat with idiopathic CD4+ T lymphocytopenia. J Vet Intern Med 2008; 22:1043–1047 [View Article][PubMed]
    [Google Scholar]
  25. Marras TK, Mendelson D, Marchand-Austin A, May K, Jamieson FB. Pulmonary nontuberculous mycobacterial disease, Ontario, Canada, 1998–2010. Emerg Infect Dis 2013; 19:1889–1891 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmmcr/10.1099/jmmcr.0.005158
Loading
/content/journal/jmmcr/10.1099/jmmcr.0.005158
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error