1 Abstract
Summary The development of new vaccines and antibody therapeutics typically takes several years and requires over $1bn in investment. Accurate knowledge of the paratope (antibody binding site) can speed up and reduce the cost of this process by improving our understanding of antibody-antigen binding. We present Paragraph, a structure-based paratope prediction tool that outperforms current state-of-the-art tools using simpler feature vectors and no antigen information.
Availability Source code is freely available at www.github.com/oxpig
Contact deane{at}stats.ox.ac.uk
Supplementary information Supplementary data are available at bioRxiv online.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.