Abstract
Longitudinal studies measuring changes in cortical morphology over time are best facilitated by parcellation schemes compatible across all life stages. The Melbourne Children’s Regional Infant Brain (M-CRIB) and M-CRIB 2.0 atlases provide voxel-based parcellations of the cerebral cortex compatible with the Desikan-Killiany (DK) and the Desikan-Killiany-Tourville (DKT) cortical labelling schemes. However, there is still a need for a surface-based approach for parcellating neonatal images using these atlases.
We introduce surface-based versions of the M-CRIB and M-CRIB 2.0 atlases, termed M-CRIB-S(DK) and M-CRIB-S(DKT), with a pipeline for automated parcellation utilizing FreeSurfer and developing Human Connectome Project (dHCP) tools.
Using T2-weighted magnetic resonance images of healthy neonates (n = 58), we created average spherical templates of cortical curvature and sulcal depth. Manually-labelled regions in a subset (n = 10) were encoded into the spherical template space to construct M-CRIB-S(DK) and M-CRIB-S(DKT) atlases. Labelling accuracy was assessed using Dice overlap measures and boundary discrepancy measures within a leave-one-out cross-validation framework.
Cross-validated labelling accuracy was high for both atlases (average regional Dice = 0.79 - 0.83). Worst-case boundary discrepancy instances ranged from 9.96 - 10.22 mm, which appeared to be driven by variability in anatomy for particular cases.
The M-CRIB-S atlases and automatic pipeline allow extraction of neonatal cortical surfaces labelled according to the DK or DKT parcellation schemes. This will facilitate surface-based investigations of brain structure at the neonatal time point. The atlases and spherical surfaces, along with customised scripts for segmentation, cortical surface extraction and parcellation, are available for public download.
Footnotes
Data availability statement: The data that support the findings of this study are openly available at https://www.github.com/DevelopmentalImagingMCRI/MCRIBS
Comparison with UNC atlas removed. Added Hausdorff distance error metric.
Abbreviations
- BSTS
- Banks of the superior temporal sulcus
- CAC
- Caudal anterior cingulate
- CMF
- Caudal middle frontal
- CUN
- Cuneus
- dHCP
- developing Human Connectome Project
- DK
- Desikan-Killiany
- DKT
- Desikan-Killiany-Tourville
- ENT
- Entorhinal
- FP
- Frontal pole
- FUS
- Fusiform
- INFP
- Inferior parietal
- INS
- Insula
- ISTC
- Isthmus cingulate
- IT
- Inferior temporal
- L+U
- Labelled+Unlabelled
- LIN
- Lingual
- LOCC
- Lateral occipital
- LOO
- Leave One Out
- LORB
- Lateral orbitofrontal
- M-CRIB
- Melbourne Children’s Regional Infant Brain
- M-CRIB-S
- Surface-based Melbourne Children’s Regional Infant Brain atlas
- MORB
- Medial orbitofrontal
- MRI
- Magnetic Resonance Imaging
- MT
- Middle temporal gyrus
- PARH
- Parahippocampal
- PARC
- Paracentral lobule
- POPE
- Pars opercularis
- PORB
- Pars orbitalis
- PCING
- Posterior cingulate
- PCAL
- Pericalcarine
- POSTC
- Posterior cingulate
- PCUN
- Precuneus
- PREC
- Precentral
- PTRI
- Pars triangularis
- RAC
- Rostral anterior cingulate
- RMF
- Rostral middle frontal
- SF
- Superior frontal
- SMAR
- Supramarginal gyrus
- SP
- Superior parietal
- ST
- Superior temporal gyrus
- TP
- Temporal pole
- TT
- Transverse temporal gyrus
- UNC
- University of North Carolina
- PMA
- Post-menstrual age
- LH
- Left hemisphere
- RH
- Right hemisphere