Perfect Conserved Linkage Across the Entire Mouse Chromosome 10 Region Homologous to Human Chromosome 21
Abstract
The distal end of human Chromosome (HSA) 21 from PDXK to the telomere shows perfect conserved linkage with mouse Chromosome (MMU) 10. This region is bounded on the proximal side by a segment of homology to HSA22q11.2, and on the distal side by a region of homology with HSA19p13.1. A high-resolution PAC-based physical map is described that spans 2.8 Mb, including the entire 2.1 Mb from Pdxk toPrmt2 corresponding to HSA21. Thirty-four expressed sequences are mapped, three of which were not mapped previously in any species and nine more that are mapped in mouse for the first time. These genes confirm and extend the conserved linkage between MMU10 and HSA21. The ordered PACs and dense STS map provide a clone resource for biological experiments, for rapid and accurate mapping, and for genomic sequencing. The new genes identified here may be involved in Down syndrome (DS) or in several genetic diseases that map to this conserved region of HSA21.
Footnotes
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Present addresses: 2Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA; 3Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544 USA.
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↵5 These authors contributed equally to this work.
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↵6 Corresponding author.
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E-MAIL rreeves{at}welchlink.welch.jhu.edu; FAX (410) 955-0461.
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- Received July 21, 1999.
- Accepted September 14, 1999.
- Cold Spring Harbor Laboratory Press
