Cellular and Molecular Mechanisms Underlying Learning and Memory Impairments Produced by Cannabinoids
Abstract
Why does smoking marijuana impair learning and memory? Behavioral studies suggest that a disruption of normal hippocampal function contributes to these deficits. In vitro experiments find that cannabinoid receptor activation reduces neurotransmitter release below the levels required to trigger long-term changes in synaptic strength in the hippocampus. Cannabinoids reduce glutamate release through a G-protein-mediated inhibition of the calcium channels responsible for neurotransmitter release from hippocampal neurons. These mechanisms likely play a role in the learning and memory impairments produced by cannabinoids and by endogenous cannabinoid receptor ligands.
Footnotes
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↵1 Corresponding author.
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E-MAIL janes{at}AXP2.Salk.edu; FAX (858) 450-2172.
- Cold Spring Harbor Laboratory Press