Qualitative and Quantitative Studies of AKR-type Murine Leukemia Virus Sequences in Mouse DNA
This extract was created in the absence of an abstract.
Excerpt
Over the past two decades, a wide variety of studies-oncologic, epidemiologic, serologic, electron microscopic, cell culture and genetic-have led to the inference that type C viral genomes can be transmitted vertically as chromosomal elements (Gross 1951; Kaplan 1967; Payne and Chubb 1968; Huebner and Todaro 1969; Stockert et al. 1971; Hanafusa et al. 1972; Todaro and Huebner 1972; Rowe 1973). This is most clear with chicken and murine type C viruses, but is likely true of many other species of vertebrates as well. This conclusion has received strong support from studies utilizing nucleic acid hybridization techniques which detected viral genetic sequences in normal cellular DNA (Bader 1966; Harel et al. 1966; Wilson and Bauer 1967; Yoshikawa-Fukada and Ebert 1969; Rosenthal et al. 1971; Varmus et al. 1972; Baluda 1972; Neiman 1972, 1973; Gelb et al. 1971, 1973; Nayak 1974). However, the significance of the hybridization results has been obscured by...
