Enzymatic Activities Associated with the SV40 Large T Antigen
This extract was created in the absence of an abstract.
Excerpt
The large SV40 T antigen is an ∼80K polypeptide (Tegtmeyer et al. 1977; Griffin et al. 1978) encoded by the early region of the virus (Carroll and Smith 1976; Greenblatt et al. 1976; Prives et al. 1977). Genetic experiments have shown it to be the cistron-A product (Tegtmeyer et al. 1975; Kuchino and Yamaguchi 1975; Alwine et al. 1975; Tenen et al. 1975). As such, it appears to serve multiple virus-specified functions. In particular, it (1) plays an essential role in the initiation of rounds of viral DNA replication (Tegtmeyer 1972; Chou and Martin 1974; Kriegler et al. 1978), (2) is active in suppressing early viral transcription and possibly acts in a positive fashion on late gene expression as well (Tegtmeyer et al. 1975; Reed et al. 1976; Alwine et al. 1977; Khoury and May 1977), and (3) plays a part in both the initiation and maintenance of SV40-mediated neoplastic...
