Synthetic Sequence-specific Ligands
This extract was created in the absence of an abstract.
Excerpt
There is much interest in the design and synthesis of chemical compounds that possess binding specificity comparable with that of bacterial repressors. These compounds could be used to affect selectively the activity of certain genes in bacterial and eukaryotic cells and might have important implications in pharmacology. In this paper we report several approaches to the design and synthesis of sequence-specific ligands.
Present knowledge of the occurrence of base-pair or base-sequence specificity among various antibiotics and drugs is restricted largely to the DNA complexes with antibiotics of the distamycin class (Zimmer et al. 1971; Zasedatelev et al. 1974, 1976; Wartell et al. 1974; Zimmer 1975; Kolchinsky et al. 1975; Gursky et al. 1977; Luck et al. 1977; Krylov et al. 1979) and to the interaction of actinomycin D (AMD) and related molecules with DNA (Gellert et al. 1965; Cerami et al. 1967; Muller and Crothers 1968, 1975).
Distamycin A (Dst)...
