Human Basic Fibroblast Growth Factor: Nucleotide Sequence, Genomic Organization, and Expression in Mammalian Cells
This extract was created in the absence of an abstract.
Excerpt
Angiogenesis, the process of new capillary growth, involves a series of steps, including the proliferation and migration of vascular endothelial cells. At the on-set of angiogenesis, existing capillaries located close to the site of an angiogenic stimulus are induced to form new sprouts. These sprouts contain dividing endothelial cells, with migrating endothelial cells at the sprout tips. Eventually, the sprouts unite and form new capillary tubes (for review, see Folkman 1985).
Angiogenesis only takes place in a limited number of circumstances; endothelial cells in capillaries and large vessels are not usually dividing. Examples of normal physiological conditions under which angiogenesis occurs include the development of the corpus luteum at the time of ovulation, the growth of the placenta and fetus during gestation, and the repair of tissue after wounding. Angiogenesis is also associated with certain disease states, including the neovascularization that surrounds a solid tumor and supports its expansion beyond...
