HLA-DQ and T-cell Receptor Genes in Insulin-dependent Diabetes Mellitus

  1. M.L. Hoover*,§,
  2. G. Angelini**,
  3. E. Ball†,
  4. P. Stastny†,
  5. J. Marks‡,
  6. J. Rosenstock†,
  7. P. Raskin†,
  8. G.B. Ferrara**,
  9. R. Tosi††, and
  10. J.D. Capra*,†,§
  1. Departments of *Microbiology, †Internal Medicine, and ‡Pediatrics, and the §Center for Diabetes Research, The University of Texas Health Center at Dallas, Dallas, Texas 75235
  2. **Instituto Tumori, Genova, Italy
  3. ††Laboratory of Cell Biology, CNR, Rome, Italy

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Polymorphism is a hallmark of the molecules encoded within the major histocompatibility complex (MHC) of humans and other mammals. The exact role of this polymorphism is still unknown, but it may be to enhance the capacity of the immune system to respond to a wide variety of antigens. For a number of years, our laboratory has been interested in defining the structural basis of the serologic specificities that map to the HLA-D region of the human major histocompatibility complex. We demonstrated previously that the HLA-DQ subregion contained genes encoding the α- and β-chains of the HLA-DQ molecule (Giles et al. 1983, 1984; Giles and Capra 1985a). We further showed that both chains of the HLA-DQ molecule were polymorphic and documented that transassociation of the constituent polypeptide chains occurred (Giles et al. 1985). We speculated that this transassociation or transcomplementation might be biologically significant because there were a number of human...

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  1. doi:10.1101/SQB.1986.051.01.093 Cold Spring Harb Symp Quant Biol 51: 803-809

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