Cyclical Changes in the Subcellular Distribution of Proteins Essential for Mitosis during Embryogenesis in Drosophila
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Excerpt
Mutations have been described that affect mitosis at three different stages of Drosophila development: in the syncytial embryo in which the division cycle consists of rapidly alternating S and M phases; in the 14th embryonic cycle when a G2 phase is introduced; and in cells of the larval central nervous system and in imaginal cells that have “conventional” cell cycles with G1, S, G2, and M phases. These categories are not absolute, and different alleles of a particular locus may show a mutant phenotype at any of these developmental stages. Nevertheless, this way of categorizing mitotic phenotypes is informative with respect to the manner in which the mitotic cycle can be regulated.
There are 13 rounds of mitosis in the first 2 hours of the development of the syncytial embryo (Zalokar and Erk 1976; Foe and Alberts 1983). These nuclear cycles have no discernible gap periods and are characterized by...
