Meiotic Chromosome Metabolism: One View
- N. Kleckner,
- R. Padmore, and
- D.K. Bishop
This extract was created in the absence of an abstract.
Excerpt
We present below a summary of recent observations from our laboratory on the events of meiotic prophase in Saccharomyces cerevisiae. These observations are presented in the context of a general view of meiosis that has evolved in our laboratory over the past several years. Complementary and contrasting views can be found in several recent reviews (Holliday 1977; Maguire 1977; Murray and Szostak 1985; Giroux 1988; Loidl 1990; Roeder 1990).
The biological function of meiosis for an individual organism is the halving in cellular chromosome complement during gametogenesis. This is accomplished by modification of the mitotic cell cycle. During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation instead of the usual single round. The second round of segregation (meiosis II; equational) is similar to that in mitosis: Sister chromatids segregate from one another. It is the first round of segregation (meiosis I; reductional) that...
