The Concept That Surveillance of Self Is Mediated Via the Same Set of Genes That Determines Recognition of Allogenic Cells
This extract was created in the absence of an abstract.
Excerpt
Effector T cells generated in virus-infected mice express two orders of specificity: one for the virus used and another for H-2 genes present in the sensitizing environment (Zinkernagel and Doherty 1974a,b, 1975, 1976; Doherty and Zinkernagel 1974; Doherty et al. 1976a). Different “clones” of virus-immune T cells are associated with each allele at H-2K or H-2D. The evidence for this contention will not be presented here since it has been discussed in detail elsewhere (Doherty et al. 1976a; Zinkernagel and Doherty 1976). Neither shall we consider again the variety of models that have been proposed to explain the phenomenon (Zinkernagel and Doherty 1974b, 1975; Katz and Benacerraf 1975, 1976; Blanden et al. 1976a). Our intention here is to develop one particular interpretation that has been crystallizing recently (Doherty et al. 1976b). This is not the only feasible hypothesis, but other viable ideas currently being explored have recently been reviewed in...
