Control of Apoptosis in Hematopoietic Cells by the Bcl-2 Family of Proteins

  1. J.M. ADAMS,
  2. D.C.S. HUANG,
  3. H. PUTHALAKATH,
  4. P. BOUILLET,
  5. G. VAIRO,
  6. K. MORIISHI,
  7. G. HAUSMANN,
  8. L. O'REILLY,
  9. K. NEWTON,
  10. S. OGILVY,
  11. M.L. BATH,
  12. C.G. PRINT,
  13. A.W. HARRIS,
  14. A. STRASSER, and
  15. S. CORY
  1. The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia

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Apoptosis, the evolutionarily conserved mechanismfor eliminating unwanted cells, is essential in multicellular organisms for normal development, tissue homeostasis, and defense against pathogens (Jacobson et al. 1997;Vaux and Korsmeyer 1999). The control of apoptosis isof considerable relevance to most biological systems, andabnormalities in its regulation can lead to cancer, autoimmunity, or degenerative disorders (Thompson 1995;O'Reilly and Strasser 1997; Strasser et al. 1997)...

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  1. doi:10.1101/sqb.1999.64.351 Cold Spring Harb Symp Quant Biol 64: 351-358

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