Thermodynamic Uncertainty Relation for Biomolecular Processes

Andre C. Barato and Udo Seifert
Phys. Rev. Lett. 114, 158101 – Published 15 April 2015
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Abstract

Biomolecular systems like molecular motors or pumps, transcription and translation machinery, and other enzymatic reactions, can be described as Markov processes on a suitable network. We show quite generally that, in a steady state, the dispersion of observables, like the number of consumed or produced molecules or the number of steps of a motor, is constrained by the thermodynamic cost of generating it. An uncertainty ε requires at least a cost of 2kBT/ε2 independent of the time required to generate the output.

  • Figure
  • Received 29 October 2014

DOI:https://doi.org/10.1103/PhysRevLett.114.158101

© 2015 American Physical Society

Authors & Affiliations

Andre C. Barato and Udo Seifert

  • II. Institut für Theoretische Physik, Universität Stuttgart, 70550 Stuttgart, Germany

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Vol. 114, Iss. 15 — 17 April 2015

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