Effective Membrane Model of the Immunological Synapse

Subhadip Raychaudhuri, Arup K. Chakraborty, and Mehran Kardar

Phys. Rev. Lett. 91, 208101 – Published 10 November 2003

Abstract

The immunological synapse is a patterned collection of different types of receptors and ligands that forms in the intercellular junction between T cells and antigen presenting cells during recognition. The synapse is implicated in information transfer between cells, and is characterized by different spatial patterns of receptors at different stages in the life cycle of T cells. We obtain a minimalist model that captures this experimentally observed phenomenology. A functional renormalization group analysis provides further insights.

Received 26 March 2003

DOI:https://doi.org/10.1103/PhysRevLett.91.208101

Authors & Affiliations

Subhadip Raychaudhuri¹, Arup K. Chakraborty^1,2,3, and Mehran Kardar⁴

¹Department of Chemical Engineering, University of California Berkeley, Berkeley, California 94720, USA
²Department of Chemistry, University of California Berkeley, Berkeley, California 94720, USA
³Material Sciences and Physical Biosciences Divisions, Lawrence Berkeley National Laboratory, University of California Berkeley, Berkeley, California 94720, USA
⁴Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

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Vol. 91, Iss. 20 — 14 November 2003

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Physical Review Letters