Budding transition of asymmetric two-component lipid domains

Jean Wolff, Shigeyuki Komura, and David Andelman
Phys. Rev. E 94, 032406 – Published 14 September 2016

Abstract

We propose a model that accounts for the budding transition of asymmetric two-component lipid domains, where the two monolayers (leaflets) have different average compositions controlled by independent chemical potentials. Assuming a coupling between the local curvature and local lipid composition in each of the leaflets, we discuss the morphology and thermodynamic behavior of asymmetric lipid domains. The membrane free-energy contains three contributions: the bending energy, the line tension, and a Landau free-energy for a lateral phase separation. Within a mean-field treatment, we obtain various phase diagrams containing fully budded, dimpled, and flat states as a function of the two leaflet compositions. The global phase behavior is analyzed, and depending on system parameters, the phase diagrams include one-phase, two-phase, and three-phase regions. In particular, we predict various phase coexistence regions between different morphologies of domains, which may be observed in multicomponent membranes or vesicles.

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  • Received 17 July 2016

DOI:https://doi.org/10.1103/PhysRevE.94.032406

©2016 American Physical Society

Physics Subject Headings (PhySH)

Physics of Living SystemsPolymers & Soft MatterStatistical Physics & ThermodynamicsCondensed Matter, Materials & Applied Physics

Authors & Affiliations

Jean Wolff*

  • Institut Charles Sadron, UPR22-CNRS 23, rue du Loess BP 84047, 67034 Strasbourg Cedex, France

Shigeyuki Komura

  • Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo 192-0397, Japan

David Andelman

  • Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel and CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China

  • *jean.wolff@ics-cnrs.unistra.fr
  • komura@tmu.ac.jp
  • andelman@post.tau.ac.il

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Issue

Vol. 94, Iss. 3 — September 2016

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