ORIGINAL ARTICLE
Lung transplantation from controlled donation after circulatory death using simultaneous abdominal normothermic regional perfusion: A single center experience

https://doi.org/10.1111/ajt.17057Get rights and content
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Despite the benefits of abdominal normothermic regional perfusion (A-NRP) for abdominal grafts in controlled donation after circulatory death (cDCD), there is limited information on the effect of A-NRP on the quality of the cDCD lungs. We aimed to study the effect of A-NRP in lungs obtained from cDCD and its impact on recipients´ outcomes. This is a study comparing outcomes of lung transplants (LT) from cDCD donors (September 2014 to December 2021) obtained using A-NRP as the abdominal preservation method. As controls, all lung recipients transplanted from donors after brain death (DBD) were considered. The primary outcomes were lung recipient 3-month, 1-year, and 5-year survival. A total of 269 LT were performed (60 cDCD and 209 DBD). There was no difference in survival at 3 months (98.3% cDCD vs. 93.7% DBD), 1 year (90.9% vs. 87.2%), and 5 years (68.7% vs. 69%). LT from the cDCD group had a higher rate of primary graft dysfunction grade 3 at 72 h (10% vs. 3.4%; p <.001). This is the largest experience ever reported with the use of A-NRP combined with lung retrieval in cDCD donors. This combined method is safe for lung grafts presenting short-term survival outcomes equivalent to those transplanted through DBD.

KEYWORDS

clinical research/practice
donors and donation
deceased
donation after circulatory death (DCD)
health services and outcomes research
lung (allograft) function/dysfunction
lung transplantation/pulmonology
organ procurement and allocation

Abbreviations

A-NRP
abdominal normothermic regional perfusion
cDCD
controlled donation after circulatory death
CIT
cold ischemic time
CLAD
chronic lung allograft dysfunction
DBD
donation after brain death
ECMO
extracorporeal membranous oxygenation
FWIT
functional warm ischemic time
ICU
intensive care unit
ISHLT
International Society for Heart and Lung Transplantation
PGD
primary lung graft dysfunction
RR
rapid recovery
WLST
withdrawal of life sustaining therapy

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