Model-based iterative reconstruction for spectral-domain optical coherence tomography

Jonathan H. Mason; Yvonne Reinwald; Ying Yang; Sarah Waters; Alicia El Haj; Pierre O. Bagnaninchi

doi:10.1117/12.2509424

21 February 2019 Model-based iterative reconstruction for spectral-domain optical coherence tomography

Jonathan H. Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, Pierre O. Bagnaninchi

Proceedings Volume 10883, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVI; 108830O (2019) https://doi.org/10.1117/12.2509424
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Spectral domain optical coherence tomography (OCT) offers high resolution multidimensional imaging, but generally suffers from defocussing, intensity falloff and shot noise, causing artifacts and image degradation along the imaging depth. In this work, we develop an iterative statistical reconstruction technique, based upon the interferometric synthetic aperture microscopy (ISAM) model with additive noise, to actively compensate for these effects. For the ISAM re-sampling, we use a non uniform FFT with Kaiser-Bessel interpolation, offering efficiency and high accuracy. We then employ an accelerated gradient descent based algorithm, to minimize the negative log-likelihood of the model, and include spatial or wavelet sparsity based penalty functions, to provide appropriate regularization for given image structures. We evaluate our approach with titanium oxide micro-bead and cucumber samples with a commercial spectral domain OCT system, under various subsampling regimes, and demonstrate superior image quality over traditional reconstruction and ISAM methods.

Citation Download Citation

Jonathan H. Mason, Yvonne Reinwald, Ying Yang, Sarah Waters, Alicia El Haj, and Pierre O. Bagnaninchi "Model-based iterative reconstruction for spectral-domain optical coherence tomography", Proc. SPIE 10883, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVI, 108830O (21 February 2019); https://doi.org/10.1117/12.2509424

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