Higher order correlation scaling for optical super-resolution imaging: implications of photon counting and quantum imaging for practical nanoscopy

Joshua Gray; Josef G. Worboys; Daniel W. Drumm; Shuo Li; Andrew D. Greentree

doi:10.1117/12.2541208

30 December 2019 Higher order correlation scaling for optical super-resolution imaging: implications of photon counting and quantum imaging for practical nanoscopy

Joshua Gray, Josef G. Worboys, Daniel W. Drumm, Shuo Li, Andrew D. Greentree

Author Affiliations +

Proceedings Volume 11202, Biophotonics Australasia 2019; 112021M (2019) https://doi.org/10.1117/12.2541208
Event: ANZCOP, 2019, Melbourne, Australia

Abstract

Techniques of optical superresolution imaging are vital for uncovering the complex dynamics of biochemistry in cellular environments. However the practical resolution for superresolution imaging is limited by the increased photon budget for superresolution, compared with conventional microscopy. For this reason it is important to determine the optimal methods for analysing all of the incoming information. Most approaches to microscopy use only the wave-like properties of light, but the particle-like nature of light provides extra information that is normally inaccessible and can be used to increase imaging resolution. Here we theoretically study the localisation of quantum emitters using higher-order quantum correlation functions to understand the resolution that is practically achievable for bio-imaging tasks. We show explicit imaging results for varying number of emitters as a function of correlation order to illustrate the necessary tradeoffs between imaging resolution and acquisition time.

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Joshua Gray, Josef G. Worboys, Daniel W. Drumm, Shuo Li, and Andrew D. Greentree "Higher order correlation scaling for optical super-resolution imaging: implications of photon counting and quantum imaging for practical nanoscopy", Proc. SPIE 11202, Biophotonics Australasia 2019, 112021M (30 December 2019); https://doi.org/10.1117/12.2541208

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