Nanopatterned structures for biomolecular analysis toward genomic and proteomic applications

Chia-Fu Chou; Jian Gu; Qihuo Wei; Yingjie Liu; Ravi Gupta; Takeyoshi Nishio; Frederic Zenhausern

doi:10.1117/12.574872

19 January 2005 Nanopatterned structures for biomolecular analysis toward genomic and proteomic applications

Chia-Fu Chou, Jian Gu, Qihuo Wei, Yingjie Liu, Ravi Gupta, Takeyoshi Nishio, Frederic Zenhausern

Proceedings Volume 5592, Nanofabrication: Technologies, Devices, and Applications; (2005) https://doi.org/10.1117/12.574872
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

We report our fabrication of nanoscale devices using electron beam and nanoimprint lithography (NIL). We focus our study in the emerging fields of NIL, nanophotonics and nanobiotechnology and give a few examples as to how these nanodevices may be applied toward genomic and proteomic applications for molecular analysis. The examples include reverse NIL-fabricated nanofluidic channels for DNA stretching, nanoscale molecular traps constructed from dielectric constrictions for DNA or protein focusing by dielectrophoresis, multi-layer nanoburger and nanoburger multiplets for optimized surface-plasma enhanced Raman scattering for protein detection, and biomolecular motor-based nanosystems. The development of advanced nanopatterning techniques promises reliable and high-throughput manufacturing of nanodevices which could impact significantly on the areas of genomics, proteomics, drug discovery and molecular clinical diagnostics.

Citation Download Citation

Chia-Fu Chou, Jian Gu, Qihuo Wei, Yingjie Liu, Ravi Gupta, Takeyoshi Nishio, and Frederic Zenhausern "Nanopatterned structures for biomolecular analysis toward genomic and proteomic applications", Proc. SPIE 5592, Nanofabrication: Technologies, Devices, and Applications, (19 January 2005); https://doi.org/10.1117/12.574872

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