Initial experimentation with in-line holography x-ray phase-contrast imaging with an ultrafast laser-based x-ray source

Andrzej Krol; Russell Kincaid; Marina Servol; Jean-Claude Kieffer; Yakov Nesterets; Tim Gureyev; Andrew Stevenson; Steve Wilkins; Hongwei Ye; Edward Lipson; Remy Toth; Andrew Pogany; Ioana Coman

doi:10.1117/12.713634

16 March 2007 Initial experimentation with in-line holography x-ray phase-contrast imaging with an ultrafast laser-based x-ray source

Andrzej Krol, Russell Kincaid, Marina Servol, Jean-Claude Kieffer, Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Steve Wilkins, Hongwei Ye, Edward Lipson, Remy Toth, Andrew Pogany, Ioana Coman

Author Affiliations +

Proceedings Volume 6510, Medical Imaging 2007: Physics of Medical Imaging; 65100L (2007) https://doi.org/10.1117/12.713634
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

We have investigated experimentally and theoretically the imaging performance of our newly constructed in-line holography x-ray phase-contrast imaging system with an ultrafast laser-based x-ray source. Projection images of nylon fibers with diameters in the 10-330 μm range were obtained using an ultrafast (100 Hz, 28 fs, 40 mJ) laser-based x-ray source with Mo and Ta targets and Be filter, and Gaussian spatial-intensity distribution (FWHMS = 5 μm). A cooled CCD camera (24 μm pitch) with a Gd₂OS₂ screen coupled via 1:1 optical taper was used (FWHMD = 50 μm). We have investigated nylon-fiber image quality vs. imaging setup geometry and x-ray spectra. The following parameters were evaluated: contrast, signal-to-noise ratio (SNR), resolution, and sampling. In addition, we performed theoretical simulation of image formation for the same objects but within a wide range of geometrical parameters. The rigorous wave-optical formalism was used for modeling of the free-space propagation of x-rays from the object plane to the detector, and the "projection approximation" was used. We found reasonable agreement between predictions of our analytical model and the experiments. We conclude that: a) Optimum magnification maximizing contrast and SNR is almost independent of the source-to-detector (R) distance and depends strongly on the diameter of the fiber. b) The corresponding maximum values of the contrast and SNR are almost linear with respect to R; the optimum magnification decreases with fiber diameter. c) The minimum diameter of fiber defines the minimum source-to-object distance R₁ if R is fixed and the object is moved.

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Andrzej Krol, Russell Kincaid, Marina Servol, Jean-Claude Kieffer, Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Steve Wilkins, Hongwei Ye, Edward Lipson, Remy Toth, Andrew Pogany, and Ioana Coman "Initial experimentation with in-line holography x-ray phase-contrast imaging with an ultrafast laser-based x-ray source", Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65100L (16 March 2007); https://doi.org/10.1117/12.713634

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