Advertisement
GET OUR E-ALERTS
No access
Report

Inhibition of Insulin Release by Norepinephrine in Man

Daniel Porte, Jr. and Robert H. WilliamsAuthors Info & Affiliations
Science
27 May 1966
Vol 152, Issue 3726
pp. 1248-1250
DOI: 10.1126/science.152.3726.1248
CHECK ACCESS

Abstract

Normal subjects were given glucose (300 mg/ min) or tolbutamide (1 g, intravenously), alone and during intravenous infusions of norepinephrine (6 μg/ min). Immunoreactive insulin concentration was less than expected during the infusions of norepinephrine, but returned to higher values after the norepinephrine infusions. From these data it is concluded that norepinephrine inhibits the release of insulin from pancreatic beta cells.

Get full access to this article

View all available purchase options and get full access to this article.

CHECK ACCESS

References

Technicon Autoanalyzer Methodology, Method File, Rev. 2-11-60 (1960).
Google Scholar
COORE, H.G., REGULATION OF INSULIN SECRETION STUDIED WITH PIECES OF RABBIT PANCREAS INCUBATED IN VITRO, BIOCHEMICAL JOURNAL 93: 66 (1964).
Google Scholar
KOSAKA, K, INSULIN-LIKE ACTIVITY IN PANCREATIC VEIN BLOOD AFTER GLUCOSE LOADING + EPINEPHRINE HYPERGLYCEMIA, ENDOCRINOLOGY 75: 9 (1964).
Google Scholar
LOUBATIERES, A, DIABETOLOGIA 1: 13 (1965).
Google Scholar
MOLINATTI, G. M., PANMINERVA MEDICA 7 3: 61 (1965).
Google Scholar
MORGAN, C.R., IMMUNAOASSAY OF INSULIN - 2 ANTIBODY SYSTEM - PLASMA INSULIN LEVELS OF NORMAL SUBDIABETIC AND DIABETIC RATS, DIABETES 12: 115 (1963).
Google Scholar
NESTEL, P.J., INFLUENCE OF FREE-FATTY-ACID METABOLISM ON GLUCOSE TOLERANCE, LANCET 2: 115 (1964).
Google Scholar
PORTE, D, EPINEPHRINE INHIBITION OF INSULIN RELEASE, JOURNAL OF CLINICAL INVESTIGATION 44: 1087 (1965).
Google Scholar
PORTE, D, EFFECT OF EPINEPHRINE ON IMMUNOREACTIVE INSULIN LEVELS IN MAN, JOURNAL OF CLINICAL INVESTIGATION 45: 228 (1966).
Google Scholar
PORTE, D, UNPUBLISHED OBSERVATIONS.
Google Scholar
RICHINS, C.A., THE INNERVATION OF THE PANCREAS, JOURNAL OF COMPARATIVE NEUROLOGY 83: 223 (1945).
Google Scholar
SAIFER, A, THE PHOTOMETRIC MICRODETERMINATION OF BLOOD GLUCOSE WITH GLUCOSE OXIDASE, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 51: 448 (1958).
Google Scholar
SAMOLS, E, COMPARISON OF INSULIN IMMUNOASSAYS, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 115: 79 (1964).
Google Scholar
SMITHWICK, R.H., PHEOCHROMOCYTOMA - A DISCUSSION OF SYMPTOMS, SIGNS AND PROCEDURES OF DIAGNOSTIC VALUE, NEW ENGLAND JOURNAL OF MEDICINE 242: 252 (1950).
Google Scholar
STOWERS, J.M., PHARMACOLOGY AND MODE OF ACTION OF THE SULPHONYLUREAS IN MAN, LANCET 1: 278 (1958).
Google Scholar
TROUT, D.L., TITRATION OF FREE FATTY ACIDS OF PLASMA - A STUDY OF CURRENT METHODS AND A NEW MODIFICATION, JOURNAL OF LIPID RESEARCH 1: 199 (1960).
Google Scholar
WURTMAN, R, NEW ENGLAND JOURNAL OF MEDICINE 273: 37 (1965).
Google Scholar

(0)eLetters

eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter.

Log In to Submit a Response

No eLetters have been published for this article yet.

Information & Authors

Information

Published In

Science
Volume 152 | Issue 3726
27 May 1966

Copyright

1966 by the American Association for the Advancement of Science.

Submission history

Published in print: 27 May 1966

Permissions

Request permissions for this article.

Authors

Affiliations

Daniel Porte, Jr.
Department of Medicine, University of Washington School of Medicine, Seattle
View all articles by this author
Robert H. Williams
Department of Medicine, University of Washington School of Medicine, Seattle
View all articles by this author

Metrics & Citations

Metrics

Article Usage

Note: The article usage is presented with a three- to four-day delay and will update daily once available. Due to this delay, usage data will not appear immediately following publication.

Citation information is sourced from Crossref Cited-by service.

Altmetrics

Citations

Cite as

  • Daniel Porte, Jr.,
  • Robert H. Williams
,
Inhibition of Insulin Release by Norepinephrine in Man.Science152,1248-1250(1966).DOI:10.1126/science.152.3726.1248

Export citation

Select the format you want to export the citation of this publication.

Cited by

    • F. C. Schuit,
    • D. G. Pipeleers,
    Differences in Adrenergic Recognition by Pancreatic A and B Cells, Science, 232, 4752, (875-877), (1986)./doi/10.1126/science.2871625
    Abstract
    • Richard J. DiRocco,
    • Harvey J. Grill,
    The Forebrain Is Not Essential for Sympathoadrenal Hyperglycemic Response to Glucoprivation, Science, 204, 4397, (1112-1114), (1979)./doi/10.1126/science.451558
    Abstract

Citation information is sourced from Crossref Cited-by service.

View Options

Check Access

Log in to view the full text

AAAS ID LOGIN

AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions.

Log in via OpenAthens.
via OpenAthens
Log in via Shibboleth.
via Shibboleth

More options

Purchase digital access to this article

Download and print this article for your personal scholarly, research, and educational use.

Purchase this issue in print

Buy a single issue of Science for just $15 USD.

View options

PDF format

Download this article as a PDF file

Download PDF

Media

Figures

Multimedia

Tables

Share

Share

Share article link

Share on social media