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Proteinase inhibitors in plant biotechnology: A review

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Abstract

Possible utilities for natural inhibitors of proteolytic enzymes in plant biotechnology have been reviewed. Among the potential areas of use of the inhibitors are (1) construction of transgenic plants with increased resistance to insects and other pests and (2) development of procedures for biosynthesis of recombinant proteins. In the latter case, the inhibitors will serve to prevent the protein degradation by proteinases.

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References

  1. Schuler, T.H., Poppy, G.M., Kerry, B.R., and Denholm, I., Trends Biotechnol., 1998, vol. 16, no. 4, pp. 168–175.

    Article  CAS  Google Scholar 

  2. Christou, P., Capell, T., Kohli, A., Gatehouse, J.A., and Gatehouse, A.M.R., Trends Plant Sci., 2006, vol. 11, no. 6, pp. 302–308.

    Article  PubMed  CAS  Google Scholar 

  3. de Maagd, R.A., Bosch, D., and Stiekema, W., Trends Plant Sci., 1999, vol. 4, no. 1, pp. 9–13.

    Article  PubMed  Google Scholar 

  4. Ferry, N., Edwards, M.G., Gatehouse, J., Capell, T., Christou, P., and Gatehouse, A.M.R., Transgenic Res., 2006, vol. 15, no. 1, pp. 13–19.

    Article  PubMed  CAS  Google Scholar 

  5. Ryan, C.A., Annu. Rev. Phytopathol., 1990, vol. 28, pp. 425–449.

    Article  CAS  Google Scholar 

  6. Mosolov, V.V. and Valueva, T.A., Prikl. Biokhim. Mikrobiol., 2005, vol. 41, no. 3, pp. 261–282.

    PubMed  CAS  Google Scholar 

  7. Daniell, H., Streatfield, S.J., and Wycoff, K., Trends Plant Sci., 2001, vol. 6, no. 5, pp. 219–226.

    Article  PubMed  CAS  Google Scholar 

  8. Fischer, R. and Emans, N., Transgenic Res., 2004, vol. 9, nos. 4–5, pp. 279–299.

    Google Scholar 

  9. Goldstein, D.A. and Thomas, J.A., QJ Med., 2004, vol. 97, no. 11, pp. 705–716.

    CAS  Google Scholar 

  10. Doran, P.M., Trends Biotechnol., 2006, vol. 24, no. 9, pp. 426–432.

    Article  PubMed  CAS  Google Scholar 

  11. Michaud, D., Recombinant Protease Inhibitors in Plants, Michaud, D., Ed., Georgetown, TX: Landes Bioscie. Eurekah. Com., 2000, pp. 1–8.

    Google Scholar 

  12. Outchkourov, N.S., Rogelj, B., Strukelj, B., and Jongsma, M.A., Plant Physiol., 2003, vol. 133, no. 1, pp. 379–390.

    Article  PubMed  CAS  Google Scholar 

  13. Bates, S.L., Zhao, J.Z., Roush, R.T., and Shelton, A.M., Nat. Biotechnol., 2005, vol. 23, no. 1, pp. 57–62.

    Article  PubMed  CAS  Google Scholar 

  14. Groot, A.T. and Dicke, M., Plant J., 2002, vol. 31, no. 4, pp. 387–406.

    Article  PubMed  CAS  Google Scholar 

  15. Oppert, B., Kramer, K.J., Johnson, D.E., Macintosh, S.C., and McGaugey, W.H., Biochem. Biophys. Res. Commun., 1994, vol. 198, no. 3, pp. 940–947.

    Article  PubMed  CAS  Google Scholar 

  16. Keller, M., Sneh, B., Strizhov, N., Prudovsky, E., Regev, A., Konaz, C., Schell, J., and Zilberstein, A., Insect. Biochem. Mol. Biol., 1996, vol. 26, no. 4, pp. 365–373.

    Article  PubMed  CAS  Google Scholar 

  17. Forcada, C., Alcacer, E., Garcera, M.D., Tato, A., and Martinez, R., Arch. Insect Biochem. Physiol., 1999, vol. 42, no. 1, pp. 51–63.

    Article  PubMed  CAS  Google Scholar 

  18. Gatehouse, J.A, Gatehouse, A.M.R, and Bown, D.P., in Recombinant Protease Inhibitors in Plants, Michaud, D., Ed., Georgetown, TX: Landes Bioscie. Eurekah. Com., 2000, pp. 9–26.

    Google Scholar 

  19. Birk, Y. and Applebaum, S.W., Enzymologia, 1960, vol. 22, no. 3, pp. 318–326.

    CAS  Google Scholar 

  20. Gatehouse, A.M.R. and Boulter, D., J. Sci. Food Agric., 1983, vol. 34, no. 2, pp. 345–350.

    Article  CAS  Google Scholar 

  21. Broadway, R.N. and Duffey, S.S., J. Insect Physiol., 1986, vol. 32, no. 10, pp. 827–833.

    Article  CAS  Google Scholar 

  22. Green, T.R. and Ryan, C.A., Science, 1972, vol. 175, no. 4, pp. 776–777.

    Article  PubMed  CAS  Google Scholar 

  23. Brown, W.E. and Ryan, C.A., Biochemistry, 1984, vol. 23, no. 15, pp. 3418–3422.

    Article  PubMed  CAS  Google Scholar 

  24. Bradshaw, H.D.F., Hollick, J.B., Parsons, T.J., Clarke, H.R.G., and Gordon, M.P., Plant. Mol. Biol., 1990, vol. 14, no. 1, pp. 51–59.

    Article  PubMed  CAS  Google Scholar 

  25. Eckelcamp, C., Ehmann, B., and Schopfer, P., FEBS Lett., 1993, vol. 323, no. 1, pp. 73–76.

    Article  Google Scholar 

  26. Moura, D.S. and Ryan, C.A., Plant Physiol., 2001, vol. 126, no. 1, pp. 289–298.

    Article  PubMed  CAS  Google Scholar 

  27. Hildmann, T., Ebneth, M., Pena-Cortes, H., Sanchez-Serrano, J.J., Willmitzer, L., and Prat, S., Plant Cell, 1992, vol. 4, no. 9, pp. 1157–1170.

    Article  PubMed  CAS  Google Scholar 

  28. Boulter, C.J., Plant Physiol., 1993, vol. 103, no. 4, pp. 1347–1353.

    Google Scholar 

  29. Graham, J.S. and Ryan, C.A., Biochem. Biophys. Res. Commun., 1981, vol. 101, no. 4, pp. 1164–1170.

    Article  PubMed  CAS  Google Scholar 

  30. Mosolov, V.V., Loginova, M.D., Fedurkina, N.V., and Benken, I.I., Plant Sci. Lett., 1976, vol. 7, no. 2, pp. 77–80.

    Article  CAS  Google Scholar 

  31. Benken, I.I., Mosolov, V.V., and Fedurkina, N.V., Mikol. Fitopatol., 1976, vol. 10, no. 3, pp. 198–201.

    Google Scholar 

  32. Valueva, T.A. and Mosolov, V.V., Biokhimiya, 2004, vol. 69, no. 11, pp. 1600–1606.

    Google Scholar 

  33. Dunaevskii, Ya.E., Elpidina, E.N., Vinokurov, K.S., and Belozerskii, M.A., Mol. Biol., 2005, vol. 39, no. 4, pp. 1–7.

    Google Scholar 

  34. Ievleva, E.V., Revina, T.A., Kudryavtseva, N.N., Sof’in, A.V., and Valueva, T.A., Prikl. Biokhim. Mikrobiol., 2006, vol. 42, no. 3, pp. 338–344.

    PubMed  CAS  Google Scholar 

  35. Gvozdeva, E.L., Volotskaya, A.V., Sof’in, A.V., Kudryavtseva, N.N., Revina, T.A., and Valueva, T.A., Prikl. Biokhim. Mikrobiol., 2006, vol. 42, no. 5, pp. 572–579.

    PubMed  CAS  Google Scholar 

  36. Pernas, M., Sanchez-Monge, R., and Salcedo, G., FEBS Lett., 2000, vol. 467, nos. 2–3, pp. 206–210.

    Article  PubMed  CAS  Google Scholar 

  37. Soares-Costa, A., Beltramini, L.M., Thiemann, O.H., and Enrique-Silva, F., Biochem. Biophys. Res. Commun., 2002, vol. 296, no. 5, pp. 1194–1199.

    Article  PubMed  CAS  Google Scholar 

  38. Martinez, M., Lopez-Solanilla, E., Rodriguez-Palenzuela, P., Carbonero, P., and Diaz, I., Mol. Plant-Microbe Interact., 2003, vol. 16, no. 10, pp. 876–883.

    Article  PubMed  CAS  Google Scholar 

  39. Yang, A.H. and Yeh, K.W., Planta, 2005, vol. 221, no. 4, pp. 493–501.

    Article  PubMed  CAS  Google Scholar 

  40. Hilder, V.A., Gatehouse, A.M.R., Sheerman, S.E., Barker, R.F., and Boulter, D., Nature, 1987, vol. 300, pp. 160–163.

    Article  Google Scholar 

  41. Johnson, R. and Narvaez, J., An G., Ryan, C.A., Proc. Natl. Acad. Sci. USA, 1989, vol. 86, no. 24, pp. 9871–9875.

    Article  PubMed  CAS  Google Scholar 

  42. Mc Manus, M.T., White, D.W.R., and Mc Gregor, P.G., Transgenic Res., 1994, vol. 3, no. 1, pp. 50–58.

    Article  CAS  Google Scholar 

  43. Yeh, K.-W., Lin, M.-I., Tuan, S.-J., Chen, Y.-M., Lin, C.-J., and Kao, S.-S., Plant Cell Rep., 1997, vol. 16, no. 10, pp. 696–699.

    Article  CAS  Google Scholar 

  44. De Leo, F., Bonade-Bottino, M.A., Ceci, L.R., Gallerani, R., and Jouanin, L., Plant Physiol., 1998, vol. 118, no. 3, pp. 997–1004.

    Article  PubMed  Google Scholar 

  45. De Leo, F., Bonade-Bottino, M.A., Ceci, L.R., Gallerani, R., and Jouanin, L., Insect Biochem. Mol. Biol., 2001, vol. 31, nos. 6–7, pp. 593–602.

    Article  PubMed  Google Scholar 

  46. Heath, R.L., Mc Donald, G., Christeller, J.T., Lee, M., Bateman, K., West, J., Van Heeswijck, R., and Anderson, M.A., J. Insect Physiol., 1997, vol. 43, no. 9, pp. 833–842.

    Article  PubMed  CAS  Google Scholar 

  47. Charity, J.A., Anderson, M.A., Bittisnich, D.J., Whitecross, M., and Higgins, T.J.V., Mol. Breeding, 1999, vol. 5, no. 4, pp. 357–365.

    Article  CAS  Google Scholar 

  48. Gatehouse, A.M.R., Davison, G.M., Newell, C.A., Merryweather, A., Hamilton, W.D.O., Burgess, E.P.J., Gilbert, R.J.C., and Gatehouse, J.A., Mol. Breeding, 1997, vol. 3, no. 1, pp. 49–63.

    Article  CAS  Google Scholar 

  49. Benchekroun, A., Michaud, D., Nguyen-Quoc, B., Overney, S., Desjardins, Y., and Yelle, S., Plant Cell Rep., 1995, vol. 14, no. 9, pp. 585–588.

    Article  CAS  Google Scholar 

  50. Xu, D., Xue, Q., Mc Elroy, D., Mawal, Y., Hilder, V.A., and Wu, R., Mol. Breeding, 1996, vol. 2, no. 2, pp. 167–173.

    Article  CAS  Google Scholar 

  51. Duan, X., Li, X., and Hue, Q., Nat. Biotechnol., 1996, vol. 14, no. 4, pp. 494–498.

    Article  PubMed  CAS  Google Scholar 

  52. Lee, S.I., Lee, S.-H., Koo, J.C., Chun, H.J., Lim, C.O., Mun, J.H., Song, Y.H., and Cho, M.J., Mol. Breeding, 1999, vol. 5, no. 1, pp. 1–9.

    Article  Google Scholar 

  53. Irie, K., Hosoyama, H., Takeuchi, T., Iwabuchi, K., Watanabe, H., Abe, K., and Arai, S., Plant. Mol. Biol., 1996, vol. 30, no. 1, pp. 149–157.

    Article  PubMed  CAS  Google Scholar 

  54. Vila, L., Quilis, J., Meynard, D., Breitler, J.C., Marfa, V., Murillo, I., Vassal, J.M., Messeguer, J., Guiderdoni, E., and San, SegundoB., Plant Biotechnol. J., 2005, vol. 3, no. 2, pp. 187–202.

    Article  PubMed  CAS  Google Scholar 

  55. Alfonso-Rubi, J., Ortego, F., Castanera, P., Carbonero, P., and Diaz, I., Transgenic Res., 2003, vol. 12, no. 1, pp. 23–31.

    Article  PubMed  CAS  Google Scholar 

  56. Rahbe, Y., Deraison, C., Bonade-Bottino, M., Girard, C., Nardon, C., and Jouanin, L., Plant Sci., 2003, vol. 164, no. 4, pp. 441–450.

    Article  CAS  Google Scholar 

  57. Graham, J.S., Gordon, S.C., and McNicol, R.J., Ann. Appl. Biol., 1997, vol. 131, no. 2, pp. 133–139.

    Article  Google Scholar 

  58. Falco, M.C. and Silva-Filho, M.C., Plant Physiol. Biochem., 2003, vol. 41, no. 8, pp. 761–766.

    Article  CAS  Google Scholar 

  59. Leple, J.C., Bonade-Bottino, M., Augustin, S., Pilate, G., Le Tan, V.D., Deplanque, A., Cornu, D., and Jouanin, L., Mol. Breeding, 1995, vol. 1, no. 4, pp. 319–328.

    Article  CAS  Google Scholar 

  60. Delledonne, M., Allegro, G., Belenghi, B., Balestrazzi, A., Picco, F., Levine, A., Zelasco, S., Calligari, P., and Confalonieri, M., Mol. Breeding, 2001, vol. 7, no. 1, pp. 35–42.

    Article  CAS  Google Scholar 

  61. Urwin, P.E., Lilley, C.J., Mc Pherson, M.J., and Atkinson, H.J., Plant J., 1997, vol. 12, no. 2, pp. 455–461.

    Article  PubMed  CAS  Google Scholar 

  62. Urwin, P.E., Levesley, A., Mc Pherson, M.J., and Atkinson, H.J., Mol. Breeding, 2004, vol. 6, no. 3, pp. 257–264.

    Article  Google Scholar 

  63. Atkinson, H.J., Grimwood, S., Johnston, K., and Green, J., Transgenic Res., 2004, vol. 13, no. 2, pp. 135–142.

    Article  PubMed  CAS  Google Scholar 

  64. Lilley, C.J., Urwin, P.E., Johnston, K.A., and Atkinson, H.J., Plant Biotechnol. J., 2004, vol. 2, no. 1, pp. 3–12.

    Article  PubMed  CAS  Google Scholar 

  65. Walker, A.J., Urwin, P.E., Atkinson, H.J., Brain, P., Glen, D.M., and Shewry, P.R., Transgenic Res., 1999, vol. 8, no. 2, pp. 95–103.

    Article  PubMed  CAS  Google Scholar 

  66. Charity, J.A., Hughes, P., Anderson, M.A., Bittisnich, D.J., Whitercross, M., and Higgins, T.J.V., Functional Plant Biol., 2005, vol. 32, no. 1, pp. 35–44.

    Article  CAS  Google Scholar 

  67. Jung, C., Cai, D., and Kleine, M., Trends Plant Sci., 1998, vol. 3, no. 7, pp. 266–271.

    Article  Google Scholar 

  68. Jongsma, M.A., Stiekema, W.J., and Bosh, D., Trends Biotechnol., 1996, vol. 14, no. 9, pp. 331–333.

    Article  CAS  Google Scholar 

  69. Oppert, B., Morgan, T.D., Hartzer, K., and Kramer, K.J., Comp. Biochem. Physiol. C, 2005, vol. 140, no. 1, pp. 53–58.

    Article  CAS  Google Scholar 

  70. Broadway, R.M., Arch. Insect Biochem. Physiol., 1996, vol. 32, no. 1, pp. 39–53.

    Article  CAS  Google Scholar 

  71. Harsulkar, A.M., Giri, A.P., Patankar, A.G., Gupta, V.S., Sainani, M.N., Ranjekar, P.K., and Deshpande, V.V., Plant Physiol., 1999, vol. 121, no. 2, pp. 497–506.

    Article  PubMed  CAS  Google Scholar 

  72. Thomas, J.C., Wasman, C.C., Echt, C., Dunn, R.L., Bohnert, H.J., and Mc Coy, T.J., Plant Cell Rep., 1994, vol. 14, no. 1, pp. 31–36.

    Article  CAS  Google Scholar 

  73. Thomas, J.C., Adams, D.G., Keppenne, V.D., Vasmann, C.C., Brown, J.K., Kanost, M.R., and Bohnert, H.J., Plant Physiol. Biochem., 1995, vol. 33, no. 5, pp. 611–614.

    CAS  Google Scholar 

  74. Kondrak, M., Kutas, J., Szenthe, B., Patty, A., Banfalvi, Z., Nadasy, M., Graf, L., and Asboth, B., Biotechnol. Lett., 2005, vol. 27, no. 12, pp. 829–834.

    Article  PubMed  CAS  Google Scholar 

  75. Christeller, J.T., Burgess, E.P.J., Mett, V., Gatehouse, H.S., Markwick, N.P., Murray, C., Malone, L.A., Wright, M.A., Philip, B.A., Watt, H.D., Gatehouse, L.N., Lovei, G.L., Shannon, A.L., Phung, M.M., Watson, L.M., and Laing, W.A., Transgenic Res., 2002, vol. 11, no. 2, pp. 161–173.

    Article  PubMed  CAS  Google Scholar 

  76. Urwin, P.E., Atkinson, H.J., Waller, D.A., and Mc Pherson, M.J., Plant J., 1995, vol. 8, no. 1, pp. 121–123.

    Article  PubMed  CAS  Google Scholar 

  77. Koiwa, H., D’Urzo, M.P., Assfalg-Machleidt, I., Zhu-Salzman, K., Shade, R.E., An, H., Murdock, L.L, Machleidt, W., Bressan, R.A., and Hasegawa, P. M., Plant J., 2001, vol. 17, no. 5, pp. 383–391.

    Article  Google Scholar 

  78. Kiggundu, A., Goulet, M.C., Goulet, C., Dubuc, J.F., Rivard, D., Benchabane, M., Pepin, G., Van der Vyver, C., Kunert, K., and Michaud, D., Plant J., 2006, vol. 48, no. 3, pp. 403–413.

    Article  PubMed  CAS  Google Scholar 

  79. Bode, W. and Huber, R., Eur. J. Biochem., 1992, vol. 204, no. 2, pp. 433–451.

    Article  PubMed  CAS  Google Scholar 

  80. Michaud, D., Trends Biotechnol., 1997, vol. 15, no. 1, pp. 4–6.

    Article  CAS  Google Scholar 

  81. Girard, C., Le Metayer, M., Bonade-Bottino, M., Pham-Delegue, M.H., and Jouanin, L., Insect Biochem. Mol. Biol., 1998, vol. 28, no. 4, pp. 229–237.

    Article  PubMed  CAS  Google Scholar 

  82. Girard, C., Le Metayer, M., Zaccomer, B., Bartlet, E., Williams, I., Bonade-Bottino, M., Pham-Delegue, M.H., and Jouanin, L., J. Insect Physiol., 1998, vol. 44, nos. 3–4, pp. 263–270.

    Article  PubMed  CAS  Google Scholar 

  83. Giri, A.P., Harsulkar, A.M., Deshpande, V.V., Sainani, M.N., Gupta, V.S., and Ranjekar, P.K., Plant Physiol., 1998, vol. 116, no. 1, pp. 391–401.

    Article  Google Scholar 

  84. Srinivasan, A.Y., Giri, A.P., and Gupta, V.S., Cell. Mol. Biol. Lett., 2006, vol. 11, no. 1, pp. 132–154.

    Article  PubMed  CAS  Google Scholar 

  85. Thie, N.M.R. and Houseman, J.G., Insect Biochem., 1990, vol. 20, no. 3, pp. 313–318.

    Article  CAS  Google Scholar 

  86. Michaud, D., Nguyen-Quoc, B., and Yelle, S., FEBS Lett., 1993, vol. 331, nos. 1–2, pp. 173–176.

    Article  PubMed  CAS  Google Scholar 

  87. Novillo, C., Castanera, P., and Ortego, F., Arch. Insect Biochem. Physiol., 1997, vol. 36, no. 3, pp. 181–201.

    Article  CAS  Google Scholar 

  88. Brunelle, F., Nguyen-Quoc, B., Cloutier, C., and Michaud, D., Arch. Insect Biochem. Physiol., 1999, vol. 42, no. 1, pp. 88–98.

    Article  PubMed  CAS  Google Scholar 

  89. Vinokurov, K.S., Elpidina, E.N., Oppert, B., Prabhakar, S., Zhuzhikov, D.P., Dunaevsky, Y.E., and Belozersky, M.A., Comp. Biochem. Physiol. B, 2006, vol. 145, no. 2, pp. 126–137.

    Article  PubMed  CAS  Google Scholar 

  90. Kouzuma, Y., Inanaga, H., Doi-Kawano, K., Yamasaki, N., and Kimura, M., J. Biochem., 2000, vol. 128, no. 2, pp. 161–166.

    PubMed  CAS  Google Scholar 

  91. Inanaga, H., Kobaysi, D., Kouzuma, Y., Aoki-Yasunaga, C., Iiyama, C., and Kimura, M., Boisci. Biotechnol. Biochem., 2001, vol. 65, no. 10, pp. 2259–2264.

    Article  CAS  Google Scholar 

  92. Brunelle, F., Girard, C., Cloutier, C., and Michaud, D., Arch. Insect Biochem. Physiol., 2005, vol. 60, no. 1, pp. 20–31.

    Article  PubMed  CAS  Google Scholar 

  93. Outchkourov, N.S., Kogel De, W.J., Wiegers, G.L., Abrahamson, M., and Jongsma, M.A., Plant Biotechnol. J., 2004, vol. 2, no. 5, pp. 449–458.

    Article  PubMed  CAS  Google Scholar 

  94. Urwin, P.E., Mc Pherson, M.J., and Atkinson, H.J., Planta, 1998, vol. 204, no. 4, pp. 472–479.

    Article  PubMed  CAS  Google Scholar 

  95. Zhu-Salzman, K., Ahn, J.-E., Salzman, R.A., Koiwa, H., Shade, R.E., and Balfe, S., Agric. Forest Ent., 2003, vol. 5, no. 4, pp. 317–323.

    Article  Google Scholar 

  96. Fan, X., Shi, X., Zhao, J., Zhao, R., and Fan, Y., Clin. J. Biotechnol., 1999, vol. 15, no. 1, pp. 1–5.

    CAS  Google Scholar 

  97. Zhang, J.H., Wang, C.Z., and Qin, J.D., J. Invertebr. Pathol., 2000, vol. 75, no. 4, pp. 259–266.

    Article  PubMed  CAS  Google Scholar 

  98. Streatfield, S.J., Plant Biotechnol. J, 2007, vol. 5, no. 1, pp. 2–15.

    Article  PubMed  CAS  Google Scholar 

  99. Karnoup, A.S., Turkelson, V., and Anderson, W.H., Glycobiology, 2005, vol. 15, no. 10, pp. 965–981.

    Article  PubMed  CAS  Google Scholar 

  100. De Neve, M., De Loose, M., Jacobs, A., Van Houdt, H., Kaluza, B., Weide, U., Van Montagu, M., and Depicker, A., Transgenic Res., 1993, vol. 2, no. 4, pp. 227–237.

    Article  PubMed  Google Scholar 

  101. Van Engelen, F.A., Schouten, A., Molthoff, J., Roosien, J., Salinas, J., Dirkse, W.G., Schots, A., Bakker, J., Gommers, F.J., Jongsma, M.A., Bosch, D., and Stiekema, W.J., Plant. Mol. Biol., 1994, vol. 26, no. 6, pp. 1701–1710.

    Article  PubMed  Google Scholar 

  102. Khoudi, H., Laberge, S., Ferullo, J.M., Bazin, R., Darveau, A., Castonguay, Y., Allard, G., Lemieux, R., and Vesina, L.P., Biotechnol. Bioeng., 1999, vol. 64, no. 2, pp. 123–149.

    Article  Google Scholar 

  103. Sharp, J.M. and Doran, P.M., Biotechnol. Bioeng., 2001, vol. 73, no. 5, pp. 338–346.

    Article  PubMed  CAS  Google Scholar 

  104. Russell, D.A., Spatoba, L.A., Dian, T., Paradkar, V.M., Dufield, D.R., Carroll, J.A., and Schlittler, M.R., Biotechnol. Bioeng., 2005, vol. 89, no. 7, pp. 775–782.

    Article  PubMed  CAS  Google Scholar 

  105. Doran, P.M., J. Biotechnol., 2006, vol. 122, no. 1, pp. 39–54.

    Article  PubMed  CAS  Google Scholar 

  106. Stevens, L.M., Stoopen, G.M., Elbers, I.J.W., Molthoff, J.W., Bakker, H.A.C., Lommen, A., Bosch, D., and Jordi, W., Plant Physiol., 2000, vol. 124, no. 1, pp. 173–182.

    Article  PubMed  CAS  Google Scholar 

  107. Yang, J., Barr, L.A., Fahnestock, S.R., and Liu, Z.-B., Transgenic Res., 2005, vol. 14, no. 3, pp. 313–324.

    Article  PubMed  CAS  Google Scholar 

  108. Schiermeyer, A., Schinkel, H., Apel, S., Fischer, R., and Schillberg, S., Biotechnol. Bioeng., 2005, vol. 89, no. 7, pp. 848–858.

    Article  PubMed  CAS  Google Scholar 

  109. Rivard, D., Anguenot, R., Brunelle, F., Le, V.Q., Vezina, L.-P., Trepanier, S., and Michaud, D., Plant Biotechnol. J., 2006, vol. 4, no. 3, pp. 359–368.

    Article  PubMed  CAS  Google Scholar 

  110. Conrad, U. and Fiedler, U., Plant. Mol. Biol., 1998, vol. 38, no. 1, pp. 101–109.

    Article  PubMed  CAS  Google Scholar 

  111. Wirth, S., Calamante, G., Mentaberry, A., Bussmann, L., Lattanzi, M., Baranao, L., and Bravo-Almonacid, F., Mol. Breed., 2004, vol. 13, no. 1, pp. 23–35.

    Article  CAS  Google Scholar 

  112. Hellwig, S., Drossard, J., Twyman, R.M., and Fischer, R., Nat. Biotechnol., 2004, vol. 22, no. 11, pp. 1415–1422.

    Article  PubMed  CAS  Google Scholar 

  113. Gruis, D., Selinger, D.A., Curran, J.M., and Jung, R., Plant Cell, 2002, vol. 14, no. 11, pp. 2863–2882.

    Article  PubMed  CAS  Google Scholar 

  114. Michaud, D., Anal. Chim. Acta, 1998, vol. 372, no. 2, pp. 173–185.

    Article  CAS  Google Scholar 

  115. Richardson, M., Phytochemistry, 1977, vol. 16, no. 2, pp. 159–169.

    Article  CAS  Google Scholar 

  116. Shain, Y. and Mayer, A.M., Physiol. Plant., 1965, vol. 18, no. 5, pp. 853–859.

    Article  CAS  Google Scholar 

  117. Ohtsubo, K., Harada, K., and Kawasaki, S., Plant Cell Physiol., 1989, vol. 30, no. 5, pp. 699–705.

    CAS  Google Scholar 

  118. Abe, K., Kondo, H., and Arai, S., Agric. Biol. Chem., 1987, vol. 51, no. 6, pp. 1509–1514.

    CAS  Google Scholar 

  119. Brzin, J., Popovic, T., Ritonja, A., Puizdar, V., and Kidric, M., Plant Sci., 1998, vol. 138, no. 1, pp. 17–26.

    Article  CAS  Google Scholar 

  120. Pompe-Novak, M., Poljak-Prijatelj, M., Popovic, T., Strukelj, B., and Ravnikar, M., Physiol. Mol. Plant Pathol., 2002, vol. 60, no. 1, pp. 71–78.

    Article  CAS  Google Scholar 

  121. Voskoboinikova, N.E., Dunaevskii, Ya.E., and Belozerskii, M.A., Biokhimiya, 1990, vol. 55, no. 5, pp. 839–847.

    CAS  Google Scholar 

  122. Xu, Z.-F., Teng, W.-L., and Chye, M.L., Planta, 2004, vol. 218, no. 4, pp. 623–629.

    Article  PubMed  CAS  Google Scholar 

  123. Kim, T.-G., Kim, H.-M., Lee, H.J., Shin, Y.-J., Kwon, T.-H., Lee, N.-J., Jang, Y.-S., and Yang, M.S., Protein Exp. Purif., 2007, vol. 53, no. 2, pp. 270–274.

    Article  CAS  Google Scholar 

  124. Komarnitsky, S., Borisjuk, N., Yakoby, N., Garvey, A., and Raskin, I., Plant Physiol., 2006, vol. 141, no. 4, pp. 1185–1193.

    Article  CAS  Google Scholar 

  125. Michaud, D., Anguenot, R., and Brunelle, F., US Patent No. 20050055746, 2005.

  126. Van der Vyver, C., Schneidereit, J., Driscoll, S., Turner, J., Kunert, K., and Foyer, C.H., Plant Biotechnol. J., 2003, vol. 1, no. 2, pp. 101–112.

    Article  PubMed  Google Scholar 

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  1. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia

    V. V. Mosolov & T. A. Valueva

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  1. V. V. Mosolov
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  2. T. A. Valueva
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Original Russian Text © V.V. Mosolov, T.A. Valueva, 2008, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2008, Vol. 44, No. 3, pp. 261–269.

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Mosolov, V.V., Valueva, T.A. Proteinase inhibitors in plant biotechnology: A review. Appl Biochem Microbiol 44, 233–240 (2008). https://doi.org/10.1134/S0003683808030010

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