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Memantine attenuates cognitive impairments after status epilepticus induced in a lithium–pilocarpine model

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Abstract

The capability of memantine, a noncompetitive antagonist of the NMDA receptors, to prevent impairments of cognitive functions in rats was investigated in the lithium–pilocarpine model of epilepsy. After status epilepticus, rats exhibited impaired exploratory behavior and spatial memory, and a decline of extinction of orienting behavior. Memantine administration prevented these disturbances. Thus, the blockade of the NMDA receptors immediately after status epilepticus allowed prevention of the development of the possible cognitive impairments.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    S. V. Kalemenev, O. E. Zubareva, V. V. Lavrent’eva, N. Ya. Lukomskaya, K. Kh. Kim, A. V. Zaitsev & L. G. Magazanik

  2. Institute of Experimental Medicine, St. Petersburg, Russia

    O. E. Zubareva & V. V. Sizov

  3. St. Petersburg State University, St. Petersburg, Russia

    L. G. Magazanik

Authors
  1. S. V. Kalemenev
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  2. O. E. Zubareva
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  3. V. V. Sizov
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  4. V. V. Lavrent’eva
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  5. N. Ya. Lukomskaya
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  6. K. Kh. Kim
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  7. A. V. Zaitsev
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  8. L. G. Magazanik
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Corresponding author

Correspondence to L. G. Magazanik.

Additional information

Original Russian Text © S.V. Kalemenev, O.E. Zubareva, V.V. Sizov, V.V. Lavrent’eva, N.Ya. Lukomskaya, K.Kh. Kim, A.V. Zaitsev, L.G. Magazanik, 2016, published in Doklady Akademii Nauk, 2016, Vol. 470, No. 6, pp. 732–735.

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Kalemenev, S.V., Zubareva, O.E., Sizov, V.V. et al. Memantine attenuates cognitive impairments after status epilepticus induced in a lithium–pilocarpine model. Dokl Biol Sci 470, 224–227 (2016). https://doi.org/10.1134/S0012496616050148

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  • DOI: https://doi.org/10.1134/S0012496616050148

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