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Status epilepticus induced by pentylenetetrazole increases short-term synaptic facilitation in the hippocampus of juvenile rats

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Abstract

We studied the effect of status epilepticus (SE) on short-term synaptic plasticity. The amplitudes of field potentials in response to extracellular stimulation of the Schaffer collaterals were recorded in hippocampal slices. Subtle modifications were revealed on day 1 after SE, whereas on days 3 and 7 we did not find any differences from the control. These data show that, one day after SE, the probability of a transmitter release in hippocampal synapses decreases that serves as a compensatory mechanism, which prevents seizure activity.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    T. Yu. Postnikova, A. M. Trofimova, A. V. Zaitsev & L. G. Magazanik

  2. Peter the Great St. Petersburg Polytechnical University, St. Petersburg, Russia

    T. Yu. Postnikova & A. M. Trofimova

  3. St. Petersburg State University, St. Petersburg, Russia

    L. G. Magazanik

Authors
  1. T. Yu. Postnikova
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  2. A. M. Trofimova
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  3. A. V. Zaitsev
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  4. L. G. Magazanik
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Corresponding authors

Correspondence to A. V. Zaitsev or L. G. Magazanik.

Additional information

Original Russian Text © T.Yu. Postnikova, A.M. Trofimova, A.V. Zaitsev, L.G. Magazanik, 2017, published in Doklady Akademii Nauk, 2017, Vol. 477, No. 5, pp. 618–621.

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Postnikova, T.Y., Trofimova, A.M., Zaitsev, A.V. et al. Status epilepticus induced by pentylenetetrazole increases short-term synaptic facilitation in the hippocampus of juvenile rats. Dokl Biol Sci 477, 207–209 (2017). https://doi.org/10.1134/S0012496617060102

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  • DOI: https://doi.org/10.1134/S0012496617060102

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