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Serotonin Modulates Differently the Functional Properties of Damaged and Intact Motoneurons in the Frog Spinal Cord

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Abstract

When studying a preparation of the isolated spinal cord segment of an adult frog, damaged and intact lumbar motoneurons were found to differ significantly in the membrane potential, input resistance and the action potential properties (amplitude, duration, fast and medium phases of the afterhyperpolarization, and the frequency of spikes). Serotonin (5-HT) reduced the amplitude of afterpolarization and increased the frequency of the spikes of the intact neurons, while in the damaged motoneurons, 5-HT increased the amplitude of afterpolarization and had no effect on the frequency of discharges.

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REFERENCES

  1. Schmidt, B.J. and Jordan, L.M., Brain Res. Bull., 2000, vol. 53, no. 5, pp. 689–710.

    Article  CAS  PubMed  Google Scholar 

  2. Murray, K.C., Stephens, M.J., Ballou, E.W., et al., J. Neurophysiol., 2011, vol. 105, pp. 731–748.

    Article  PubMed  Google Scholar 

  3. Alvarez, F.J., Pearson, J.C., Harrington, D., et al., J. Comp. Neurol., 1998, vol. 393, pp. 69–83.

    Article  CAS  PubMed  Google Scholar 

  4. Xia, Y., Chen, D., Xia, H., et al., Neurosci. Let., 2017, vol. 649, pp. 70–77.

    Article  CAS  Google Scholar 

  5. Davies, M.L., Kirov, S.A., and Andrew, R.D., J. Neurosci. Methods, 2007, vol. 166, pp. 203–216.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Carp, J.S., Tennissen, A.M., Mongeluzi, D.L., et al., J. Neurophysiol., 2008, vol. 100, pp. 474–481.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Kalinina, N.I., Kurchavyi, G.G., Zaitsev, A.V., and Vesselkin, N.P., J. Evol. Biochem. Physiol., 2016, vol. 52, no. 5, pp. 359–368.

  8. Kalinina, N.I., Zaitsev, A.V., and Vesselkin, N.P., J. Comp. Physiol. A, 2018, vol. 204, no. 3, pp. 329–337.

    Article  CAS  Google Scholar 

  9. Dityatev, A.E., Chmykhova, N.M., Dityateva, G.V., et al., J. Comp. Neurol., 2001, vol. 430, pp. 433–447.

    Article  CAS  PubMed  Google Scholar 

  10. Diaz-Rios, M., Dombeck, D.A., Webb, W.W., and Harris-Warrick, R.M., J. Neurophysiol., 2007, vol. 98, pp. 2157–2167.

    Article  CAS  PubMed  Google Scholar 

  11. Hsiao, C.F., Trueblood, P.R., Levine, M.S., and Chandler, S.H., J. Neurophysiol., 1997, vol. 77, pp. 2910–2924.

    Article  CAS  PubMed  Google Scholar 

  12. Miles, G.B. and Sillar, K.T., Physiology, 2011, vol. 26, pp. 393–441.

    Article  CAS  PubMed  Google Scholar 

  13. Perrier, J-F., Rasmussen, H.B., Christensen, R.K., and Petersen, A.V., Curr. Pharm. Des., 2013, vol. 19, no. 24, pp. 4371–4384.

    Article  CAS  PubMed  Google Scholar 

  14. Sah, P., TIN, 1996, vol. 19, no. 4, pp. 150–154.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223, St. Petersburg, Russia

    N. I. Kalinina, A. V. Zaitsev &  N. P. Vesselkin

  2. Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia

    A. V. Zaitsev

  3. St. Petersburg State University, 199034, St. Petersburg, Russia

    N. P. Vesselkin

Authors
  1. N. I. Kalinina
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  2. A. V. Zaitsev
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  3. N. P. Vesselkin
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Corresponding authors

Correspondence to N. I. Kalinina or A. V. Zaitsev.

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Translated by A. Nikolaeva

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Kalinina, N.I., Zaitsev, A.V. & Vesselkin, N.P. Serotonin Modulates Differently the Functional Properties of Damaged and Intact Motoneurons in the Frog Spinal Cord. Dokl Biol Sci 484, 5–9 (2019). https://doi.org/10.1134/S0012496619010046

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  • DOI: https://doi.org/10.1134/S0012496619010046

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