Skip to main content
Log in

Somatovisceral intersystemic interactions in newborn rat pups under decreased motor activity

  • Comparative and Ontogenic Physiology
  • Published:
Journal of Evolutionary Biochemistry and Physiology Aims and scope Submit manuscript

Abstract

Interaction of slow-wave rhythmic components of cardiac, respiratory and motor activities was investigated in newborn rat pups on the first day after birth under normal conditions and after pharmacological depression of spontaneous periodic motor activity (SPMA) induced by injection of myocuran (myanesin) at low (100 mg/pg, i/p) and maximal (235 mg/pg, i/p) doses. The data obtained indicate that in rat pups after birth the intersystemic interactions are realized mainly via slow-wave oscillations of the near-minute or multiminute ranges, whereas the rhythms of the decasecond range do not play a significant role in integrative processes. Injection of myocuran at a dose causing neither muscle relaxation nor inhibition of motor activity induces changes in the cardiac and respiratory rhythms as well as a transitory decrease in the magnitude of coordinating relations mediated by the rhythms of the near-minute and multiminute ranges. The consequences of myorelaxant injection were found to be more significant for intersystemic interactions with the involvement of the respiratory system. The increase in the myocuran dose and, correspondingly, complete inhibition of SPMA is accompanied by the reduction in the slow-wave components of the pattern of cardiac and respiratory rhythms. The cardiorespiratory interactions, more pronounced in intact rat pups, decrease in the near-minute and multiminute modulation ranges and increase insignificantly in the decasecond modulation range.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kuznetsov, S.V., Sizonov, V.A., and Dmitrieva, L.E., A change in the character of intersystemic interactions in newborn rat pups under conditions of decreased central influences (urethane anesthesia), J. Evol. Biochem. Physiol., 2014, vol. 50, no. 3, pp. 234–246.

    Article  CAS  Google Scholar 

  2. Bursian, A.V., Dmitrieva, L.E., and Sizonov, V.A., Effect of changes in the level of motor activity and innervation on the basic and secondary rhythms of heartbeats and respiration in rat ontogenesis, J. Evol. Biochem. Physiol., 2011, vol. 47, no. 4, pp. 366–373.

    Article  Google Scholar 

  3. Sizonov, V.A., Dmitrieva, L.E., and Kuznetsov, S.V., Somatovisceral intersystemic interactions in newborn rat pups, XXII S”ezd Fiziol. Obsch. im. I.P. Pavlova, Volgograd, 2013, p. 480.

    Google Scholar 

  4. Wyngarden, J.B., Tieche, H.L., and Seevers, M.H., On the pharmacology of myanesin, with particular reference to its intramuscular administration, Anesthesiol., 1949, vol. 10, iss. 5, pp. 529–543.

    Article  Google Scholar 

  5. Stephen, C.R. and Chandy, J., Clinical and experimental studies with myanesin (a preliminary report), Can. Med. Assoc. J., 1947, vol. 57, no. 5, pp. 463–468.

    PubMed Central  Google Scholar 

  6. Schlesinger, E.B., Drew, A.L., and Wood, B., Clinical studies in the use of myanesin, Am. J. Med., 1948, vol. 4, no. 3, pp. 365–372.

    Article  CAS  PubMed  Google Scholar 

  7. Kaada, B.R., Site of action of myanesin (mephenesin, tolserol) in the central nervous system, J. Neurophysiol., 1950, vol. 13, no. 1, pp. 89–104.

    CAS  PubMed  Google Scholar 

  8. Griffith, H.R. and Cullen, W.G., Myanesin as a muscle relaxant, Curr. Res. Anesth. Analg., 1948, vol. 27, iss. 4, pp. 232–235

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. V. Kuznetsov.

Additional information

Original Russian Text © V.A. Sizonov, L.E. Dmitrieva, S.V. Kuznetsov, 2015, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2015, Vol. 51, No. 4, pp. 290—298.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sizonov, V.A., Dmitrieva, L.E. & Kuznetsov, S.V. Somatovisceral intersystemic interactions in newborn rat pups under decreased motor activity. J Evol Biochem Phys 51, 332–341 (2015). https://doi.org/10.1134/S0022093015040092

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0022093015040092

Key words

Navigation