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Electrical activity of the neocortex in adult rats after prenatal hypoxia and in epilepsy model

  • Comparative and Ontogenic Physiology
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Abstract

Changes in electrical activity of the neocortex after prenatal hypoxia (day 14 of embryogenesis, E14, 7% O2 for 3 h) and intracortical microinjection of epileptogenic 4-aminopyridine (4-AP) were studied in adult (3-month-old) rats. The frequency–time parameters of electrocorticogram (ECoG) were analyzed during sleep and wakefulness as well as in a model of 4-AP-induced spike-wave discharge (SWD) epileptiform activity. The results showed that in rats exposed to prenatal hypoxia the theta rhythm had a lower frequency while sleep spindles displayed a lower spectral power in the low-frequency range as compared to the control group. In rats with prenatal pathology, there was revealed a delayed onset of epileptiform activity and a shifted frequency distribution of the SWD spectral power induced by 4-AP.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    D. S. Kalinina, O. S. Alekseeva & I. A. Zhuravin

  2. St. Petersburg State University, St. Petersburg, Russia

    A. B. Vol’nova

  3. St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia

    I. A. Zhuravin

Authors
  1. D. S. Kalinina
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  2. A. B. Vol’nova
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  3. O. S. Alekseeva
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  4. I. A. Zhuravin
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Correspondence to I. A. Zhuravin.

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Original Russian Text © D.S. Kalinina, A.B. Vol’nova, O.S. Alekseeva, I.A. Zhuravin, 2016, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2016, Vol. 52, No. 5, pp. 321—327.

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Kalinina, D.S., Vol’nova, A.B., Alekseeva, O.S. et al. Electrical activity of the neocortex in adult rats after prenatal hypoxia and in epilepsy model. J Evol Biochem Phys 52, 352–358 (2016). https://doi.org/10.1134/S0022093016050033

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  • DOI: https://doi.org/10.1134/S0022093016050033

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