Skip to main content
SpringerLink
Log in

d-metal folates and the folic acid–imidazole conjugate

  • Physical Chemistry of Solutions
  • Published:
Russian Journal of Inorganic Chemistry Aims and scope Submit manuscript

Abstract

Metal folates MFol • nH2O (M2+ = Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+; n = 4–6), silver folate Ag2Fol • 3H2O, and the folic acid–imidazole conjugate H2Fol • 3Im • 2H2O were synthesized in aqueous solutions at a 1 : 1 M2+ : H2Fol molar ratio and pH 5.5–6.6. The compositions of the resulting compounds were determined by chemical, thermal, and gravimetric analysis. The composition of copper(II) folate was confirmed by elemental analysis; the solubility product of nickel folate (9.65 × 10–9) was estimated using solubility data. IR and electron absorption spectroscopy was used to show that oxygen atoms of carboxyl groups in folic acid and the pyridine nitrogen atom in imidazole are involved in bond formation in folates and the conjugate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. O. Shnaidman, Production of Vitamins (Pishchevaya Promyshlennost, Moscow, 1973) [in Russian].

    Google Scholar 

  2. B. L. Hutchings, Patent US 2470490 publ. 1949.

    Google Scholar 

  3. E. Kuh and J. Smith, Patent US 2474184 publ. 1949.

    Google Scholar 

  4. G. A. Sofronov, M. S. Ukader, I. D. Frizen, et al., Patent RU 2132686 (1999).

    Google Scholar 

  5. B. A. Kamen and A. K. Smith, Adv. Drug Deliv. Rev. 56, 1085 (2004).

    Article  CAS  Google Scholar 

  6. Lu Veiyu, Liu Min, and Pan Yun. Patent RU 2280650 publ. 2006.

    Google Scholar 

  7. T. A. Pavich, A. V. Vorobei, S. M. Arabei, and K. N. Solov’ev, Zh. Prikl. Spectrosk. 79, 664 (2012).

    Google Scholar 

  8. A. N. Eremin, G. K. Zhavnerko, and V. E. Agabekov, Dokl. NAN Belarusi 55 (4), 54 (2011).

    CAS  Google Scholar 

  9. A. V. Abakshonok, A. N. Eremin, V. E. Agabekov, and G. K. Zhavnerko, Ross. Bioterapevt. Zh. 12 (2), 2 (2013).

    Google Scholar 

  10. I. A. Milevich, S. A. Vorob’eva, and A. I. Lesnikovich, Vestn. Bel. Gos. Univ., Ser. 2, No. 1, 30 (2011).

    Google Scholar 

  11. J. Pfiffner, S. Binkley, and E. Bloom, and B. O’Dell, J. Am. Chem. Soc. 69, 1476 (1947).

    Article  CAS  Google Scholar 

  12. L. V. Korol’chenko, T. Ya. Sakharnaya, E. L. Pidemskii, et al., Patent RU 739884 publ. 2006.

    Google Scholar 

  13. L. V. Simak, T. B. Karpova, E. L. Pidemskii, et al., Patent RU 585684 (2006).

    Google Scholar 

  14. R. Dawson, D. Elliott, W. Elliott, and K. Jones, Data for Biochemical Research (Clarendon, Oxford, 1986).

    Google Scholar 

  15. U. Radzhobov, Doctorate Dissertation in Chemistry (Dushanbe, 2011).

    Google Scholar 

  16. I. M. Sharipov, Candidate Dissertation in Pharmaceutical Science (Samara, 2014).

    Google Scholar 

  17. V. P. Parini, Usp. Khim. 31, 822 (1982).

    Google Scholar 

  18. A. N. Isaev, Ross. Khim. Zh. 51 (5), 34 (2007).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Tomsk State University, Tomsk, Russia

    N. A. Skorik

Authors
  1. N. A. Skorik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. A. Skorik.

Additional information

Original Russian Text © N.A. Skorik, 2015, published in Zhurnal Neorganicheskoi Khimii, 2015, Vol. 60, No. 11, pp. 1531–1536.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Skorik, N.A. d-metal folates and the folic acid–imidazole conjugate. Russ. J. Inorg. Chem. 60, 1402–1406 (2015). https://doi.org/10.1134/S0036023615110145

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0036023615110145

Keywords

Search

Navigation