Abstract
It seems relevant to study the relationship between body mass index (BMI), cognitive function, and characteristics of cerebral blood flow in chronic cerebral ischemia (CCI). To demonstrate a link between BMI, and cognitive function and cerebral blood flow in patients with CCI. We examined 83 patients (29 men and 54 women) with CCI and without type 2 diabetes mellitus. We measured the BMI and assessed cognitive function using the Montreal Cognitive Assessment (MoCA) test. Duplex scanning was used to measure the volumetric cerebral blood flow rate in the main cerebral arteries. The correlation between BMI, results of the MoCA and volumetric cerebral blood flow rate in the major cerebral arteries was evaluated using parametric and non-parametric statistical tests. Patients with CCI were found to have a statistically significant Spearman’s rank correlation between BMI and age (R = –0.41; p = 0.0001). BMI correlated with the volumetric blood flow rate in the internal carotid arteries (R = 0.32; p = 0.005). A correlation was found between BMI and the results of the MoCA. Partial correlation coefficients confirmed a statistically significant association between BMI, MoCA test results and the volumetric blood flow rate in the left ICA, when the age of patients with CCI was controlled. The study of correlations between BMI, MoCA test results and the volumetric blood flow rate in the left ICA demonstrated greater psychophysiological preservation in patients with CCI who had a higher BMI, as compared to patients with CCI who had a lower BMI. These data should be considered when developing recommendations for the prevention and treatment of CCI in patients.
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Fokin, V.F., Medvedev, R.B., Ponomareva, N.V. et al. Body Mass Index, Cerebrovascular Indicators and Cognitive Function in Patients with Chronic Cerebral Ischaemia. Hum Physiol 47, 884–890 (2021). https://doi.org/10.1134/S0362119721080053
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DOI: https://doi.org/10.1134/S0362119721080053