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Voltammetric determination of droxidopa in the presence of carbidopa using a nanostructured base electrochemical sensor

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Abstract

A novel carbon paste electrode modified with ZnO nanorods and 2-(4-oxo-3-phenyl-3,4-dihydroquinazolinyl)-N′-phenyl-hydrazinecarbothioamide (2PHCZNCPE) was fabricated and employed to study the electrocatalytic oxidation of droxidopa, using cyclic voltammetry, chronoamperometry and square wave voltammetry as diagnostic techniques. It has been found that the oxidation of droxidopa at the surface of modified electrode occurs at a potential of about 435 mV less positive than that of an unmodified carbon paste electrode. Square wave voltammetry exhibits a linear dynamic range from 7.0 × 10–8 to 3.0×10−4 M and a detection limit of 45.0 nM for droxidopa. Finally this modified electrode was used for simultaneous determination of droxidopa and carbidopa.

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Correspondence to Hadi Mahmoudi Moghaddam.

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Published in Russian in Elektrokhimiya, 2017, Vol. 53, No. 5, pp. 515–525.

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Moghaddam, H.M., Beitollahi, H., Tajik, S. et al. Voltammetric determination of droxidopa in the presence of carbidopa using a nanostructured base electrochemical sensor. Russ J Electrochem 53, 452–460 (2017). https://doi.org/10.1134/S1023193517050123

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