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Supersensitive Registration of Polyfunctional Magnetic Nanomaterials for the Rapid Detection of Molecular Markers of Diseases

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Abstract

Magnetic particles based on superparamagnetic iron oxide nanocrystals find increasing application in the development of modern techniques for high-precision express determination of biomolecule concentrations. In this work, based on an original technique for the ultrasensitive detection of nonlinear magnetic nanomaterials, we develop a universal method for the use of magnetic particles as polyfunctional agents that simultaneously perform several different functions in a single assay for topical tasks of biochemical and medical diagnostics. The method is tested for the rapid quantitative detection of cardiac markers and SARS-CoV-2-associated molecular markers in complex matrices. The proposed method is promising for creating test systems for prehospital monitoring, in particular, emergency molecular diagnostics in patients with a suspected acute myocardial infarction, and the rapid detection of the coronavirus infection.

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REFERENCES

  1. P. I. Nikitin, P. M. Vetoshko, and T. I. Ksenevich, Sens. Lett. 5, 296 (2007). https://doi.org/10.1166/sl.2007.007

    Article  CAS  Google Scholar 

  2. E. C. Welch et al., Adv. Funct. Mater. 31, 2104126 (2021). https://doi.org/10.1002/adfm.202104126

  3. A. S. Drozdov et al., Int. J. Mol. Sci. 24, 134 (2023). https://doi.org/10.3390/ijms24010134

    Article  CAS  Google Scholar 

  4. J. Yoon et al., Materials 13, 299 (2020). https://doi.org/10.3390/ma13020299

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  5. V. A. Bragina et al., Anal. Chem. 91, 9852 (2019). https://doi.org/10.1021/acs.analchem.9b01519

    Article  CAS  PubMed  Google Scholar 

  6. W. Ling et al., J. Mater. Res. 34, 1828 (2019). https://doi.org/10.1557/jmr.2019.129

    Article  ADS  CAS  Google Scholar 

  7. R. P. Gambhir, S. S. Rohiwal, and A. P. Tiwari, Appl. Surf. Sci. Adv. 11, 100303 (2022). https://doi.org/10.1016/j.apsadv.2022.100303

  8. P. Chandrasekharan et al., Theranostics 10, 2965 (2020). https://doi.org/10.7150/thno.40858

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. K. Wu et al., ACS Appl. Mater. Interfaces 13, 44136 (2021). https://doi.org/10.1021/acsami.1c14657

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. S. L. Znoyko et al., Talanta 216, 120961 (2020). https://doi.org/10.1016/j.talanta.2020.120961

  11. D. Rosenblum et al., Nat. Commun. 9, 1410 (2018). https://doi.org/10.1038/s41467-018-03705-y

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  12. M. N. Alves et al., Trends Anal. Chem. 114, 89 (2019). https://doi.org/10.1016/j.trac.2019.02.026

    Article  CAS  Google Scholar 

  13. K. Wu et al., ACS Appl. Mater. Interfaces 14, 9945 (2022). https://doi.org/10.1021/acsami.1c20141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. J. Choi et al., Biosens. Bioelectron. 85, 1 (2016). https://doi.org/10.1016/j.bios.2016.04.046

    Article  ADS  CAS  PubMed  Google Scholar 

  15. I. Ennen et al., Sensors 16, 904 (2016). https://doi.org/10.3390/s16060904

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  16. K. Enpuku et al., Supercond. Sci. Technol. 30, 053002 (2017). https://doi.org/10.1088/1361-6668/aa5fce

  17. A. Vettoliere, P. Silvestrini, and C. Granata, in Quantum Materials, Devices, and Applications, Ed. by M. Henini and M. O. Rodrigues (Elsevier, Amsterdam, 2023), p. 43. https://doi.org/10.1016/B978-0-12-820566-2.00001-6

    Book  Google Scholar 

  18. J.-H. Storm et al., Appl. Phys. Lett. 110, 072603 (2017). https://doi.org/10.1063/1.4976823

  19. S.-Y. Yang et al., J. Nanobiotechnol. 14, 41 (2016). https://doi.org/10.1186/s12951-016-0198-5

    Article  CAS  Google Scholar 

  20. S. Uchida et al., IEEE Trans. Appl. Supercond. 24 (4), 1 (2014). https://doi.org/10.1109/TASC.2014.2311449

    Article  Google Scholar 

  21. S. Wissberg et al., Sci. Rep. 10, 1573 (2020). https://doi.org/10.1038/s41598-020-58307-w

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  22. A. V. Orlov, D. O. Novichikhin, A. V. Pushkarev, Yu. A. Malkerov, S. L. Znoiko, N. V. Guteneva, N. N. Orlova, B. G. Gorshkov, and P. I. Nikitin, Dokl. Phys. 67, 193 (2022). https://doi.org/10.1134/S1028335822070035

    Article  ADS  CAS  Google Scholar 

  23. T. L. Krasnikova, P. I. Nikitin, T. I. Ksenevich, B. G. Gorshkov, A. V. Orlov, M. V. Sidorova, A. A. Az- muko, T. I. Arefieva, E. N. Mamochkina, E. E. Efremov, and Zh. D. Bespalova, Dokl. Biol. Sci. 433, 289 (2010). https://doi.org/10.1134/S0012496610040150

    Article  CAS  PubMed  Google Scholar 

  24. A. V. Orlov et al., Molecules 27, 8077 (2022). https://doi.org/10.3390/molecules27228077

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. A. V. Orlov et al., Int. J. Mol. Sci. 23, 4474 (2022). https://doi.org/10.3390/ijms23094474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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ACKNOWLEDGMENTS

The authors thank I.L. Nikitina for fruitful discussions and help in preparing the manuscript.

Funding

Different parts of this interdisciplinary study were supported in part by the Russian Science Foundation, project no. 19-73-10205 (the development of analytical systems for the determination of molecular cardiac biomarkers and 3D immunochromatographic analysis) and no. 18-74-10098 (the development of biosensor platforms for detection of SARS-CoV-2-associated molecular markers).

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Authors and Affiliations

  1. Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991, Moscow, Russia

    A. V. Orlov, Yu. A. Malkerov, A. M. Skirda, D. O. Novichikhin, S. L. Znoyko, V. A. Bragina & P. I. Nikitin

  2. National Research Nuclear University MEPhI, 115409, Moscow, Russia

    Yu. A. Malkerov, A. M. Skirda & D. O. Novichikhin

Authors
  1. A. V. Orlov
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  2. Yu. A. Malkerov
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  3. A. M. Skirda
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  4. D. O. Novichikhin
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  5. S. L. Znoyko
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  6. V. A. Bragina
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  7. P. I. Nikitin
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Corresponding authors

Correspondence to A. V. Orlov or P. I. Nikitin.

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Translated by E. Bondareva

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Orlov, A.V., Malkerov, Y.A., Skirda, A.M. et al. Supersensitive Registration of Polyfunctional Magnetic Nanomaterials for the Rapid Detection of Molecular Markers of Diseases. Dokl. Phys. 68, 214–218 (2023). https://doi.org/10.1134/S1028335823070054

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