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NAP Family Histone Chaperones: Characterization and Role in Ontogenesis

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Abstract

Histone chaperones are a class of proteins that bind and transport histones, preventing their chaotic aggregation when forming nucleosomes. Histone chaperones of the NAP (Nucleosome Assembly Protein) family contain a highly conserved central NAP domain, which is necessary for histone binding and nucleosome assembly. They are an essential component in creating and maintaining the eukaryotic chromatin dynamics on which the transcription of many genes depends. The review considers the NAP family of proteins and its specific representatives: NAP1, NAP2, and CG5017/Hanabi. Since they are canonical histone transporters providing effective chromatin remodeling, NAP family proteins are involved in neuronal differentiation, spermatogenesis, and long-term memory formation, which indicates the importance of this family in ontogenesis.

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Funding

The research was funded by the Russian Foundation for Basic Research, project number 20-04-00272а, and was performed within the framework of State Assignment of Koltzov Institute of Developmental Biology (Russian Academy of Sciences), year 2020, no. 0108-2019-0001, Molecular and Genetic Mechanisms of the Regulation of Cell Differentiation and Morphogenesis.

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  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    A. A. Akishina, E. E. Kuvaeva, Y. E. Vorontsova & O. B. Simonova

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  1. A. A. Akishina
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  2. E. E. Kuvaeva
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  3. Y. E. Vorontsova
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  4. O. B. Simonova
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Correspondence to O. B. Simonova.

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This paper does not contain any studies involving animals or human participants performed by the authors.

AUTHOR CONTRIBUTIONS

A.A. Akishina and E.E. Kuvaeva equally contributed: they analyzed the world literature and wrote the main text of the article. Yu.E. Vorontsova participated in editing and discussion the article’s text. O.B. Simonova initiated the writing of the review and edited the text.

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Translated by A. Ermakov

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Akishina, A.A., Kuvaeva, E.E., Vorontsova, Y.E. et al. NAP Family Histone Chaperones: Characterization and Role in Ontogenesis. Russ J Dev Biol 51, 343–355 (2020). https://doi.org/10.1134/S1062360420060028

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  • DOI: https://doi.org/10.1134/S1062360420060028

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