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Biological activity and pharmacological prospects of lupane terpenoids: I. natural lupane derivatives

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Abstract

The biological activity of natural and semisynthetic lupane triterpenoids is discussed in a two-part review. The first part is devoted to the pharmacological properties of natural lupane triterpenoids. Betulinic acid has proven to be the most effective antitumor agent among more than fifty natural lupanes.

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Authors and Affiliations

  1. Vorozhtsov Institute of Organic Chemistry, Novosibirsk, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrents’eva 9, Novosibirsk, 630090, Russia

    T. G. Tolstikova, I. V. Sorokina & G. A. Tolstikov

  2. Institute of Technical Chemistry, Ural Division, Russian Academy of Sciences, ul. Lenina 13a, Perm, 614990, Russia

    A. G. Tolstikov

  3. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054, Russia

    O. B. Flekhter

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  1. T. G. Tolstikova
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  2. I. V. Sorokina
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  3. G. A. Tolstikov
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  4. A. G. Tolstikov
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  5. O. B. Flekhter
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Correspondence to A. G. Tolstikov.

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Original Russian Text © T.G. Tolstikova, I.V. Sorokina, G.A. Tolstikov, A.G. Tolstikov, O.B. Flekhter, 2006, published in Bioorganicheskaya a Khimiya, 2006, Vol. 32, No. 1, pp. 42–55.

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Tolstikova, T.G., Sorokina, I.V., Tolstikov, G.A. et al. Biological activity and pharmacological prospects of lupane terpenoids: I. natural lupane derivatives. Russ J Bioorg Chem 32, 37–49 (2006). https://doi.org/10.1134/S1068162006010031

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  • DOI: https://doi.org/10.1134/S1068162006010031

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