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Biological activity and pharmacological prospects of lupane terpenoids: II. Semisynthetic lupane derivatives

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Abstract

The discussion of lupane triterpenoids as prospective medicinal preparations is continued, and semisynthetic triterpenoids are being discussed. Acyl derivatives that mainly exhibit high anti-HIV, antitumor, and organoprotective activities are described.

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Abbreviations

BA:

betulinic acid

EC:

effective concentration

TI:

therapeutic index

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Authors and Affiliations

  1. Vorozhtsov Institute of Organic Chemistry, Novosibirsk, Siberian Division, Russian Academy of Sciences, pr. akademika Lavrent’eva 9, Novosibirsk, 630090, Russia

    T. G. Tolstikova, I. V. Sorokina & G. A. Tolstikov

  2. Institute of Technical Chemistry, Ural Division, Russian Academy of Sciences, ul. Lenina 13a, Perm, 614990, Russia

    A. G. Tolstikov

  3. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054, Russia

    O. B. Flekhter

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  1. T. G. Tolstikova
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  2. I. V. Sorokina
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  3. G. A. Tolstikov
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  5. O. B. Flekhter
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Original Russian Text © T.G. Tolstikova, I.V. Sorokina, G.A. Tolstikov, A.G. Tolstikov, O.B. Flekhter, 2006, published in Bioorganicheskaya Khimiya, 2006, Vol. 32, No. 3, pp. 291–307.

For Part I, see [1].

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Tolstikova, T.G., Sorokina, I.V., Tolstikov, G.A. et al. Biological activity and pharmacological prospects of lupane terpenoids: II. Semisynthetic lupane derivatives. Russ J Bioorg Chem 32, 261–276 (2006). https://doi.org/10.1134/S1068162006030083

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