Skip to main content
SpringerLink
Log in

Branched antimicrobial peptides

  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract

Branched peptides E(RLAR)2, E[E(RLAR)2]2, and E(KLAR)2, E[E(KLAR)2]2 were synthesized on the basis of tetrapeptides RLAR and KLAR and glutamic acid bis(pentafluorophenyl) ester. Their minimal antimicrobial concentrations were shown to decrease along with increase in branching, achieving 12 μM for Escherichia coli cells, which is comparable to antimicrobial activities of temporin, magainin, and dermaseptin. The branched peptides were found not to act on human erythrocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

MIC:

minimal inhibiting concentration

References

  1. Travis, J., Science, 1994, vol. 264, pp. 360–362.

    Article  PubMed  CAS  Google Scholar 

  2. Neu, H.C., Science, 1992, vol. 257, pp. 1064–1073.

    Article  PubMed  CAS  Google Scholar 

  3. Hancock, R.E.W. and Scott, M.G., Proc. Natl. Acad. Sci. USA, 2000, vol. 97, pp. 8856–8861.

    Article  PubMed  CAS  Google Scholar 

  4. Zasloff, M., Nature, 2002, vol. 415, pp. 389–395.

    Article  PubMed  CAS  Google Scholar 

  5. Tossi, A., Sandri, L., and Giangaspero, A., Biopolymers, 2000, vol. 55, pp. 4–30.

    Article  PubMed  CAS  Google Scholar 

  6. Op de Kamp, Y.A.F., Annu. Rev. Biochem., 2001, vol. 48, pp. 47–71.

    Article  Google Scholar 

  7. Shai, Yc. and Oren, Z., Peptides, 2001, vol. 22, pp. 1622–1641.

    Article  Google Scholar 

  8. Boman, H.G., Cell, 1991, vol. 65, pp. 205–207.

    Article  PubMed  CAS  Google Scholar 

  9. Blazyk, J., Wiegand, R., Klein, J., Hammer, J., Epand, R.M., Epand, R.F., Maloy, W.L., and Kari, U.P., J. Biol. Chem., 2001, vol. 276, pp. 27 899–27 906.

    Article  CAS  Google Scholar 

  10. Ryadnov, M.G., Degtyareva, O.V., Kashparov, I.A., and Mitin, Yu.V., Biokhimiya (Moscow), 2003, vol. 68, pp. 1049–1054.

    Google Scholar 

  11. Date, M., Nikolenko, H., Meyer, J., Beyermann, M., and Bienert, M., FEBS Lett., 2001, vol. 501, pp. 146–150.

    Article  Google Scholar 

  12. Kisfaludy, L., Löw, M., Nyeki, O., et al., Liebigs Ann. Chem., 1973, no. 9, pp. 1421–1429.

  13. Castano, S., Desbad, B., and Dufourg, J., Biochim. Biophys. Acta, 2000, vol. 1463, pp. 68–80.

    Google Scholar 

  14. Ondetti, M.A., J. Am. Chem. Soc., 1970, vol. 92, pp. 195–197.

    Article  PubMed  CAS  Google Scholar 

  15. Gershkovich, A.A. and Kibirev, V.K., Sintez peptidov. Reagenty i metody (Synthesis of Peptides: Reagents and Methods), Kiev: Naukova dumka, 1992.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    A. Yu. Khrushchev, I. A. Kashparov, L. V. Klimenko & Yu. V. Mitin

  2. Faculty of Chemistry, Krasnoyarsk State University, pr. Svobodnyi 79, Krasnoyarsk, 660041, Russia

    A. Yu. Khrushchev

Authors
  1. A. Yu. Khrushchev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. A. Kashparov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. V. Klimenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu. V. Mitin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu. V. Mitin.

Additional information

Original Russian Text © A.Yu. Khrushchev, I.A. Kashparov, L.V. Klimenko, Yu.V. Mitin, 2007, published in Bioorganicheskaya Khimiya, 2007, Vol. 33, No. 6, pp. 588–592.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khrushchev, A.Y., Kashparov, I.A., Klimenko, L.V. et al. Branched antimicrobial peptides. Russ J Bioorg Chem 33, 544–548 (2007). https://doi.org/10.1134/S1068162007060027

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162007060027

Key words

Search

Navigation