Abstract
The synthetic methods for new 2-, 2,2′-, and 3-substituted 4,4′-bis(chloromethyl)biphenyls were developed. Quaternization of them with various amines resulted in a series of new double quaternary ammonium salts containing the biphenyl moiety. The majority of the obtained compounds have a pronounced antifungal and antibacterial activity against the Gram-positive bacteria.
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References
Bemis, G.W. and Murcko, M., J. Med. Chem., 1996, vol. 39, p. 2887.
Hajduk, P.H., Bures, M., Praestgaard, J., and Fesik, S.W., J. Med. Chem., 2000, vol. 43, p. 3443.
Labrie, F., Singh, Sh.M., and Vab Luu-The, USA Patent no. 6933321, 2005.
Russell, R. and Murray, W.V., USA Patent no. 5252753, 1993.
Dunkel, R., Elbe, H.-L., Reick, H., Wachendorff-Neumann, U., and Kuck, K.-H., WO Patent no. 035555 A1, 2004.
Reick, H., Dunkel, R., Elbe, H.-L., Wachendorff-Neumann, U., Mauler-Machnik, A., and Kuck, K.-H., WO Patent no. 069995 A1, 2003.
Fischer, R., Ullmann, A., Bretscheneider, T., Drewes, M., Erdeler, Ch., Feucht, D., Reckmann, U., Kuck, K.-H., and Wachendorff-Neumann, U., WO Patent no. 045957 A1, 2003.
Ol’khovik, V.K., Vasilevskii, D.A., Pap, A.A., Kalechits, G.V., Metveienko, Yu.V., Baran, A.G., Galinovskii, N.A., and Petushok, V.G., Arkivoc, 2008, no. 9, p. 69.
Ol’khovik, V.K., Vasilevskii, D.A., Pap, A.A., Galinovskii, N.A., and Tereshko, S.N., Zh. Org. Khim., 2008, vol. 44, no. 8, p. 1185.
Krasil’nikov, A.P., Spravochnik po antiseptike (Antiseptic Handbook), Minsk: Vysshaya Shkola, 1995.
Metodicheskie rekomendatsii po ispytaniyu khimicheskikh veshchestv na fungitsidnuyu aktivnost’ (Guidelines for Testing of Chemicals on the Fungicidal Activity), Andreeva, E.I. and Kartomysheva, V.G., Eds., Cherkassy: NPO “Zashchita rastenii,” VNII KhSZR, 1990.
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Original Russian Text © V.K. Ol’khovik, Yu.V. Matveienko, D.A. Vasilevskii, G.V. Kalechits, R.A. Zheldakova, 2013, published in Zhurnal Obshchei Khimii, 2013, Vol. 83, No. 2, pp. 275–281.
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Ol’khovik, V.K., Matveienko, Y.V., Vasilevskii, D.A. et al. Synthesis, antimicrobial and antifungal activity of double quaternary ammonium salts of biphenyls. Russ J Gen Chem 83, 329–335 (2013). https://doi.org/10.1134/S1070363213020163
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DOI: https://doi.org/10.1134/S1070363213020163