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Synthesis of some novel 2-thioxoimidazolidin-4-one substituted glycosyl hydrazone derivatives

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Abstract

A series of novel 2-thioxoimidazolidine glycosides were prepared via reaction of the key intermediate 2-(benzylsulfanyl)-5-[4-(3-hydroxypropoxy)-3-(methoxybenzylidene)]-3-phenyl-1H-imidazol-4-one with different sugar aldose or sugar hydrazones to give the corresponding glycosides. The newly synthesized compounds were confirmed by physical and spectral data.

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Authors and Affiliations

  1. Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    N. M. Khalifa, M. A. Al-Omar & A. E. Amr

  2. Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    N. M. Khalifa

  3. Chemical Industries Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    A. A. Sediek & A. E. Amr

  4. Chemistry Department, Faculty of Sciences and Arts, Al-Kamil Branch, University of Jeddah, Jeddah, Saudi Arabia

    A. A. Sediek

Authors
  1. N. M. Khalifa
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  2. M. A. Al-Omar
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  3. A. A. Sediek
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  4. A. E. Amr
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Corresponding author

Correspondence to N. M. Khalifa.

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The text was submitted by the authors in English.

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Khalifa, N.M., Al-Omar, M.A., Sediek, A.A. et al. Synthesis of some novel 2-thioxoimidazolidin-4-one substituted glycosyl hydrazone derivatives. Russ J Gen Chem 87, 523–529 (2017). https://doi.org/10.1134/S1070363217039239

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  • DOI: https://doi.org/10.1134/S1070363217039239

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