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Synthesis and Antioxidant Activity of N-Aminomethyl Derivatives of Ethosuximide and Pufemide Anticonvulsants

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Abstract

Aminomethylation of 3-methyl-3-ethylpyrrolidin-2,5-dione (ethosuximide) and 3-(4-isopropoxyphenyl)pyrrolidine-2,5-dione (pufemide) with a 25% aqueous formalin solution and alkyl(aryl)amines yielded corresponding N-aminomethyl derivatives. The antioxidant activity of the synthesized compounds and their effect on some parameters of the blood coagulation system were studied.

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Authors and Affiliations

  1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 0014, Yerevan, Armenia

    N. Z. Hakobyan, Z. A. Hovasyan, S. S. Hovakimyan, A. G. Melkonyan, N. A. Pagutyan, G. A. Panosyan & G. A. Gevorgyan

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  1. N. Z. Hakobyan
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  2. Z. A. Hovasyan
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  3. S. S. Hovakimyan
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  4. A. G. Melkonyan
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  5. N. A. Pagutyan
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  6. G. A. Panosyan
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  7. G. A. Gevorgyan
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Correspondence to G. A. Gevorgyan.

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Hakobyan, N.Z., Hovasyan, Z.A., Hovakimyan, S.S. et al. Synthesis and Antioxidant Activity of N-Aminomethyl Derivatives of Ethosuximide and Pufemide Anticonvulsants. Russ J Gen Chem 90, 385–389 (2020). https://doi.org/10.1134/S1070363220030093

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  • DOI: https://doi.org/10.1134/S1070363220030093

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