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One-Pot Synthesis of Papaverine Hydrochloride and Identification of Impurities

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Abstract

A one-pot synthesis of papaverine hydrochloride with 99.6% purity was performed using xylene as solvent for the entire process. The critical parameters of each step, as well as the impurities generated, were identified. The overall yield was improved to 63%. The proposed synthetic procedure is suitable for industrial production.

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Funding

We thank the Engineering Research Center for the Improvement & Industrialization of Pharmaceutical Processes for financial support.

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Authors and Affiliations

  1. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 110016, Shenyang, China

    Wen-Shuai Yu & Chun-Jie Zhao

  2. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 201203, Shanghai, China

    Wen-Shuai Yu, Ze-Nong Wu, Fu-Li Zhang & Zhe-Zhou Yang

  3. School of Pharmacy, Fudan University, 201203, Shanghai, China

    Ze-Nong Wu

  4. College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, China

    Zeng-Feng Qiu

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  1. Wen-Shuai Yu
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  2. Ze-Nong Wu
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  3. Zeng-Feng Qiu
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  4. Chun-Jie Zhao
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  5. Fu-Li Zhang
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Correspondence to Chun-Jie Zhao.

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Yu, WS., Wu, ZN., Qiu, ZF. et al. One-Pot Synthesis of Papaverine Hydrochloride and Identification of Impurities. Russ J Org Chem 56, 1295–1299 (2020). https://doi.org/10.1134/S1070428020070258

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  • DOI: https://doi.org/10.1134/S1070428020070258

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