Abstract
The inotropic and chronotropic effects of neodymium ions (Nd3+) on the heart muscle of a frog Rana ridibunda and the influence of Nd3+ on respiration, swelling, and potential (∆Ψmito) of Ca2+-loaded rat heart mitochondria (RHM) were studied. It was found that Nd3+ reduced the amplitude and frequency of spontaneous heart contraction (Fmax); Nd3+ also prevented a short-term increase in Ca2+-induced basal respiration of mitochondria and their swelling in salt media, as well as a decrease of ∆Ψmito on the inner mitochondrial membrane (IMM). At the same time, Nd3+ slightly affected mitochondrial respiration in state 3 or in 2,4-dinitrophenol (DNP)-uncoupled state. These effects of Nd3+ may indicate that Nd3+ inhibits the mitochondrial permeability transition pore (MPTP) opening, which is formed in calcium loaded mitochondria. The data obtained are important for a better understanding of the mechanisms of action of rare earth elements on Ca2+-dependent processes in the myocardium of vertebrates.
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Korotkov, S.M., Sobol, C.V., Schemarova, I.V. et al. Effects of Nd3+ on Calcium-Dependent Processes in Isolated Rat Heart Mitochondria and Frog Heart Muscle. Biochem. Moscow Suppl. Ser. A 13, 161–167 (2019). https://doi.org/10.1134/S1990747819070018
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DOI: https://doi.org/10.1134/S1990747819070018