Abstract
During recent decades significant progress in studies of the molecular basis of socially significant diseases has been achieved due to introduction of high-throughput methods of genomics and proteomics. Numerous studies, performed within the global program “Human Proteome,” were aimed at identifying all possible proteins in various (including cancer) cell cultures and tissues. One of the aims was to identify socalled biomarkers—the proteins, specific for certain pathologies. However, many studies have shown that the development of the disease is not associated with appearance of new proteins, but it depends on the expression level of certain genes or specific proteoforms representing splice variants, single amino acid polymorphism (SAP) and post-translational modifications (PTM) of proteins. PTMs can play a key role in the development of pathology, because they activate various regulatory or structural proteins in most cellular processes. Among such modifications, phosphorylation appears to be the most significant PTM. This review considers methods of analysis of protein phosphorylation used in studies of the molecular basis of oncological diseases; it contains examples illustrating contribution of modified proteins directly involved in their development as well as examples of screening of such crucial PTMs in diagnostics and selection of methods for treatment.
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Shruthi, B.S., Vinodhkuma, P., and Selvamani P., Adv. Biomed. Res., 2016, vol. 5, p. 67. doi 10.4103/2277-9175.180636
Corbo, C., Cevenini, A., and Salvatore, F., Proteomics— Clinical Applications, 2017, 1600072. doi 10.1002/prca.201600072
Kang, C., Lee, Y., and Lee, J.E., W. J. Gastroenterol., 2016, vol. 22, pp. 8283–8293. doi 10.3748/wjg.v22.i37.8283
Di Meo, A., Pasic, M.D., Yousef, G.M., Di Meo, A., Pasic, M.D., and Yousef, G.M., Oncotarget, 2015, vol. 7, pp. 52460–52474. doi 10.18632/oncotarget. 8931
Naruzhnyi, S.N., Ronzhina, N.L., Mainskova, M.A., Belyakova, N.V., Pantina, R.A., and Filatov, M.V., Biomed. Khim., 2014, vol. 60, pp. 308–321. doi 10.18097/pbmc20146003308
Wasylishen, A.R. and Lozano, G., Cold Spring Harb. Perspect. Med., 2016, vol. 6, a026211. doi 10.1101/cshperspect. a026211
Harris, T.J.R. and McCormick, F., Nat. Rev. Clin. Oncol., 2010, vol. 7, pp. 251–265. doi 10.1038/nrclinonc. 2010.41
Irby, R.B. and Yeatman, T.J., Oncogene, 2000, vol. 19, pp. 5636–5642. doi 10.1038/sj.onc.1203912
Mármol, I., Sánchez-de-Diego, C., Dieste, A.P., Cerrada, E., and Yoldi, M.R., Int. J. Mol. Sci., 2017, vol. 18, p. 197. doi 10.3390/IJMS18010197
Lee, M.J. and Yaffe, M.B., Cold Spring Harb. Perspect. Biol., 2016, vol. 8, a005918. doi 10.1101/cshperspect. a005918
Hernández-Monge, J., Rousset-Roman, A.B.A., Medina-Medina, I., and Olivares-Illana, V., Genes and Cancer, 2016, vol. 7, pp. 278–287. doi 10.18632 genesandcancer. 120
Krueger, K.E. and Srivastava, S., Mol. Cell. Proteomics, 2006, vol. 5, pp. 1799–1810. doi 10.1074/mcp.R600009-MCP200
Bertram, J.S., Molecular Aspects of Medicine, 2000, vol. 21, pp. 167–223. doi 10.1016/S0098-2997(00)00007-8
Hornbeck, P.V., Zhang, B., Murray, B., Kornhauser, J.M., Latham, V., and Skrzypek, E., Nucleic Acids Res., 2015, vol. 43, D512–D520. doi 10.1093/nar/gku1267
Burnett, G. and Kennedy, E.P., J. Biol. Chem., 1954, vol. 211, pp. 969–980.
Rikova, K., Guo, A., Zeng, Q., Possemato, A., Yu, J., Haack, H., Nardone, J., Lee, K., Reeves, C., Li, Y., Hu, Y., Tan, Z., Stokes, M., Sullivan, L., Mitchell, J., Wetzel, R., MacNeill, J., Ren, J.M., Yuan, J., Bakalarski, C. E., Villen, J., Kornhauser, J. M., Smith, B., Li, D., Zhou, X., Gygi, S.P., Gu, T.-L., Polakiewicz, R.D., Rush, J., and Comb, M.J., Cell, 2007, vol. 131, pp. 1190–1203. doi 10.1016/j.cell.2007.11.025
Roskoski, R., Pharmacol. Res., 2014, vol. 79, pp. 34–74. doi 10.1016/j.phrs.2013.11.002
Pópulo, H., Lopes, J.M., and Soares, P., Int. J. Mol. Sci., 2012, vol. 13, pp. 1886–1918. doi 10.3390/ijms13021886
Matallanas, D., Birtwistle, M., Romano, D., Zebisch, A., Rauch, J., von Kriegsheim, A., and Kolch, W., Genes Cancer, 2011, vol. 2, pp. 232–260. doi 10.1177/1947601911407323
Yang, S.X., Polley, E., and Lipkowitz, S., Cancer Treatment Rev., 2016, vol. 45, pp. 87–96. doi 10.1016/j.ctrv.2016.03.004
García-Carracedo, D., Ángeles Villaronga, M., Álvarez-Teijeiro, S., Hermida-Prado F., Santamaría, I., Allonca, E., Suárez-Fernández, L., Gonzalez, M.V., Balbín, M., Astudillo, A., Martínez-Camblor, P., Su, G.H., Rodrigo, J.P., and García-Pedrero, J.M., Oncotarget, 2016, vol. 7, pp. 29780–29793. doi 10.18632/oncotarget.8957
Bubici, C. and Papa, S., Br. J. Pharmacol., 2014, vol. 171, pp. 24–37. doi 10.1111/bph.12432
Davies, C. and Tournier, C., Biochem. Soc. Trans., 2012, vol. 40, pp. 85–89. doi 10.1042/BST20110641
Rutherford, C., Speirs, C., Williams, J.J.L., Ewart, M.-A., Mancini, S.J., Hawley, S.A., Delles, C., Viollet, B., Costa-Pereira, A.P., Baillie, G.S., Salt, I.P., and Palmer, T.M. Sci. Signal., 2016, vol. 9, no. 453, ra109. doi 10.1126/scisignal.aaf8566
Jiang, M.-C., Tumor Biology, 2016, vol. 37, pp. 13077–13090. doi 10.1007/s13277-016-5301-x
Dyson, N.J., Genes Dev., 2016, vol. 30, pp. 1492–1502. doi 10.1101/gad.282145.116
Gully, C.P., Velazquez-Torres, G., Shin, J.-H., Fuentes-Mattei, E., Wang, E., Carlock, C., Chen, J., Rothenberg, D., Adams, H.P., Choi, H.H., Guma, S., Phan, L., Chou, P.-C., Su, C.-H., Zhang, F., Chen, J.-S., Yang, T.-Y., Yeung, S.-C.J., and Lee, M.-H., Proc. Natl. Acad. Sci. USA, 2012, vol. 109, E1513–E1522. doi 10.1073/pnas.1110287109
Rector, J., Kapil, S., Treude, K.J., Kumm, P., Glanzer, J.G., Byrne, B.M., Liu, S., Smith, L.M., DiMaio, D.J., Giannini, P., Smith, R.B., and Oakley, G.G., Oncotarget, 2016, vol. 8, pp. 9243–9250. doi 10.18632/oncotarget.14001
Miguel-Luken, M.J. de, Chaves-Conde, M., Quintana, B., Menoyo, A., Tirado, I., Miguel-Luken, V. de, Pachón, J., Chinchón, D., Suarez, V., and Carnero, A., Oncotarget, 2016, vol. 7, pp. 31723–31737. doi 10.18632/oncotarget.9172
Okayama, A., Kimura, Y., Miyagi, Y., Oshima, T., Oshita, F., Ito, H., Nakayama, H., Nagashima, T., Rino, Y., Masuda, M., Ryo, A., and Hirano, H., J. Proteomics, 2016, vol. 139, pp. 60–66. doi 10.1016/j.jprot.2016.03.005
Carter, J.H., Deddens, J.A., Spaulding, N.R., Lucas, D., Colligan, B.M., Lewis, T.G., Hawkins, E., Jones, J., Pemberton, J.O., Douglass, L.E., and Graff, J.R., Br. J. Cancer, 2016, vol. 114, pp. 444–453. doi 10.1038/bjc.2015.450
Piersma, S.R., Knol, J.C., De Reus, I., Labots, M., Sampadi, B.K., Pham, T.V., Ishihama, Y., Verheul, H.M.W., and Jimenez, C.R., J. Proteomics, 2015, vol. 127, pp. 247–258. doi 10.1016/j.jprot. 2015.03.019
Schunter, A.J., Yue, X., and Hummon, A.B., Anal. Bioanal. Chem., 2017, vol. 409, pp. 1749–1763. doi 10.1007/s00216-016-0125-5
Schweppe, D.K., Rigas, J.R., and Gerber, S.A., J. Proteomics, 2013, vol. 91, pp. 286–296. doi 10.1016/j.jprot.2013.07.023
Klammer, M., Kaminski, M., Zedler, A., Oppermann, F., Blencke, S., Marx, S., Muller, S., Tebbe, A., Godl, K., and Schaab, C., Mol. Cell. Proteomics, 2012, vol. 11, pp. 651–668. doi 10.1074/mcp.M111.016410
Tan, X., Liu, P., Huang, Y., Zhou, L., Yang, Y., Wang, H., Yu, B., Meng, X., Zhang, X., and Gao, F., PLoS One, 2016, vol. 11, e0152280. doi 10.1371/journal. pone.0152280
Casado, P., Alcolea, M.P., Iorio, F., Rodríguez-Prados, J.-C., Vanhaesebroeck B., Saez-Rodriguez, J., Joel, S., and Cutillas, P.R., Genome Biol., 2013, vol. 14, R37. doi 10.1186/gb-2013-14-4-r37
Pinto-Leite, R., Arantes-Rodrigues, R., Sousa, N., Oliveira, P.A., and Santos, L., Tumor Biology, 2016, vol. 37, pp. 11541–11551. doi 10.1007/s13277-016-5083-1
Akl, M.R., Nagpal, P., Ayoub, N.M., Tai, B., Prabhu, S.A., Capac, C.M., Gliksman, M., Goy, A., and Suh, K.S., Oncotarget, 2016, vol. 7, no. 28, pp. 44735–44762. doi 10.18632/oncotarget.8203
Asati, V., Mahapatra, D.K., and Bharti, S.K., Eur. J. Med. Chem., 2016, vol. 109, pp. 314–341. doi 10.1016/j.ejmech.2016.01.012
Booy, E.P., Johar, D., Maddika, S., Pirzada, H., Sahib, M.M., Gehrke, I., Loewen, S., Louis, S.F., Kadkhoda, K., Mowat, M., and Los, M., Arch. Immunol. Ther. Exp. (Warsz.), 2006, vol. 54, pp. 85–101. doi 10.1007/s00005-006-0011-5
Greenhalgh, J., Bagust, A., Boland, A., Dwan, K., Beale, S., Hockenhull, J., Proudlove, C., Dundar, Y., Richardson, M., Dickson, R., Mullard, A., and Marshall, E., Health Technol. Assess., 2015, vol. 19, pp. 1–134. doi 10.3310/hta19470
Tiwari, S.R., Mishra, P., and Abraham, J., Clinical Breast Cancer, 2016, vol. 16, pp. 344–348. doi 10.1016/j.clbc.2016.05.016
Segovia-Mendoza, M., González-González, M.E., Barrera, D., Díaz, L., and García-Becerra, R., Am. J. Cancer Res., 2015, vol. 5, pp. 2531–2561. PMC4633889
Qiu, P., Wang, S., Liu, M., Ma, H., Zeng, X., Zhang, M., Xu, L., Cui, Y., Xu, H., Tang, Y., He, Y., and Zhang L., BMC Cancer, 2017, vol. 17, p. 55. doi 10.1186/s12885-016-3039-x
Haas-Kogan, D.A., Prados, M.D., Tihan, T., Eberhard, D.A., Jelluma, N., Arvold, N.D., Baumber, R., Lamborn, K.R., Kapadia, A., Malec, M., Berger, M.S., Stokoe, D., J. Natl. Cancer Inst., 2005, vol. 97, pp. 880–887. doi 10.1093/jnci/dji161
Mellinghoff, I.K., Wang, M.Y., Vivanco, I., Haas-Kogan, D.A., Zhu, S., Dia, E.Q., Lu, K.V., Yoshimoto, K., Huang, J.H.Y., Chute, D.J., Riggs, B.L., Horvath, S., Liau, L.M., Cavenee, W.K., Rao P.N., Beroukhim, R., Peck, T.C., Lee, J.C., Sellers, W.R., Stokoe, D., Prados, M., Cloughesy, T.F., Sawyers, C.L., and Mischel, P.S., N. Engl. J. Med., 2005, vol. 353, pp. 2012–2024. doi 10.1056/NEJMoa051918
Matei, D., Chang, D.D., and Jeng, M.-H., Clin. Cancer Res., 2004, vol. 10, doi 10.1158/1078-0432.CCR-0754-03
Tuchen, M., Wilisch-Neumann, A., Daniel, E.A., Baldauf, L., Pachow, D., Scholz, J., Angenstein, F., Stork, O., Kirches, E., and Mawrin, C., Eur. J. Cancer, 2017, vol. 73, pp. 9–21. doi 10.1016/j.ejca.2016.12.004
Zhong, D., Xiong, L., Liu, T., Liu, X., Liu, X., Chen, J., Sun, S.-Y., Khuri, F.R., Zong, Y., Zhou, Q., and Zhou, W., J. Biol. Chem., 2009, vol. 284, pp. 23225–23233. doi 10.1074/jbc.M109.005280
Machida, K., Eschrich, S., Li, J., Bai, Y., Koomen, J., Mayer, B.J., and Haura, E.B., PLoS One, 2010, vol. 5, e13470. doi 10.1371/journal.pone.0013470
Zhang, X., Belkina, N., Jacob, H.K.C., Maity, T., Biswas, R., Venugopalan, A., Shaw, P. G., Kim, M.-S., Chaerkady, R., Pandey, A., and Guha, U., Proteomics, 2015, vol. 15, pp. 340–355. doi 10.1002/pmic.201400315
Guo, A., Villen, J., Kornhauser, J., Lee, K.A., Stokes, M.P., Rikova, K., Possemato, A., Nardone, J., Innocenti, G., Wetzel, R., Wang, Y., MacNeill, J., Mitchell, J., Gygi, S.P., Rush, J., Polakiewicz, R.D., Comb, M.J., Proc. Natl. Acad. Sci. USA, 2008, vol. 105, pp. 692–697. doi 10.1073/pnas.0707270105
Paweletz, C.P., Charboneau, L., Bichsel, V.E., Simone, N.L., Chen, T., Gillespie, J.W., Emmert-Buck, M.R., Roth, M.J., Petricoin, E.F., and Liotta, L.A., Oncogene, 2001, vol. 20, pp. 1981–1989. doi 10.1038/sj.onc.1204 265
Rapkiewicz, A., Espina, V., Zujewski, J.A., Lebowitz, P.F., Filie, A., Wulfkuhle, J., Camphausen, K., Petricoin, E.F., Liotta, L.A., and Abati, A., Cancer, 2007, vol. 111, pp. 173–184. doi 10.1002/cncr.22686
Sheehan, K.M., Mol. Cell. Proteomics, 2005, vol. 4, pp. 346–355. doi 10.1074/mcp.T500003-MCP200
Zhang, H. and Pelech, S., Semin. Cell. Dev. Biol., 2012, vol. 23, pp. 872–882.
Brumbaugh, K., Johnson, W., Liao, W.-C., Lin, M.-S., Houchins, J.P., Cooper, J., Stoesz, S., and Campos-Gonzalez, R., Meth. Mol. Biol., 2011, vol. 717, pp. 3–43. doi 10.1007/978-1-61779-024-9_1
Liotta, L.A., Espina, V., Mehta, A.I., Calvert, V., Rosenblatt, K., Geho, D., Munson, P.J., Young, L., Wulfkuhle, J., and Petricoin, E.F., Cancer Cell, 2003, vol. 3, pp. 317–325. doi 10.1016/S1535-6108(03)00086-2
Labots, M., Gotink, K.J., Dekker, H., Azijli K Mijn., Huijts, C.M., Piersma S.R., Jiménez, C.R., and Verheul, H.M.W., Experimental and Molecular Medicine, 2016, vol. 48, e279. doi 10.1038/emm.2016.114
Penque, D., Proteomics—Clin. Appl., 2009, vol. 3, no. 2, pp. 155–172. doi 10.1002/prca.200800025
Miller, I., Crawford, J., and Gianazza, E., Proteomics, 2006, vol. 6, pp. 5385–5408. doi 10.1002/pmic.200600323
Pal, M., Moffa, A., Sreekumar, A., Ethier, S.P., Barder, T.J., Chinnaiyan, A., and Lubman, D.M., Anal. Chem., 2006, vol. 78, pp. 702–710. doi 10.1021/ac0511243
Kaufmann, H., Bailey, J.E., and Fussenegger, M., Proteomics, 2001, vol. 1, pp. 194–199. doi 10.1002/1615-9861(200102)1:2<194::AID-PROT194>3.0.CO;2-K
Lin, H.-J., Hsieh, F.-C., Song, H., and Lin, J., Br. J. Cancer, 2005, vol. 93, pp., 1372–1381. doi 10.1038/sj.bjc.6602862
Lisitsa, A., Moshkovskii, S., Chernobrovkin, A., Ponomarenko, E., and Archakov, A., Exp. Rev. Proteomics, 2014, vol. 11, pp. 121–129. doi 10.1586/14789450.2014.878652
Beausoleil, S.A., Villén, J., Gerber, S.A., Rush, J., and Gygi, S.P., Nat. Biotechnol., 2006, vol. 24, pp. 1285–1292. doi 10.1038/nbt1240
Savitski, M.M., Lemeer, S., Boesche, M., Lang, M., Mathieson, T., Bantscheff, M., and Kuster, B., Mol. Cell. Proteomics, 2011, vol. 10, M110.003830-M110.003830. doi 10.1074/mcp.M110.003830
Taus, T., Köcher, T., Pichler, P., Paschke, C., Schmidt, A., Henrich, C., and Mechtler, K., J. Proteome Res., 2011, vol. 10, pp. 5354–5362. doi 10.1021/pr200611n
Nakagami, H., Sugiyama, N., Mochida, K., Daudi, A., Yoshida, Y., Toyoda, T., Tomita, M., Ishihama, Y., and Shirasu, K., Plant Physiol., 2010, vol. 153, pp. 1161–1174. doi 10.1104/pp.110.157347
Schroeder, M.J., Shabanowitz, J., Schwartz, J.C., Hunt, D.F., and Coon, J.J., Anal. Chem., 2004, vol. 76, pp. 3590–3598. doi 10.1021/ac0497104
Beck, A., Deeg, M., Moeschel, K., Schmidt, E.K., Schleicher, E.D., Voelter, W., Häring, H.U., and Lehmann, R., Rapid Commun. Mass Spectrom., 2001, vol. 15, pp. 2324–2333. doi 10.1002/rcm.511
Steen, H., Küster, B., Fernandez, M., Pandey, A., and Mann, M., Anal. Chem., 2001, vol. 73, pp. 1440–1448.
Mann, M., Ong, S.E., Grønborg, M., Steen, H., Jensen, O.N., and Pandey, A., Trends in Biotechnology, 2002, vol. 20, pp. 261–268. doi 10.1016/S0167-7799(02)01944-3
Huang, J., Wang, F., Ye, M., and Zou, H. J. Chromatogr. A, 2014, vol. 1372, pp. 1–17. doi 10.1016/j.chroma.2014.10.107
Olsen, J.V., Vermeulen, M., Santamaria, A., Kumar, C., Miller, M.L., Jensen, L.J., Gnad, F., Cox, J., Jensen, T.S., Nigg, E.A., Brunak, S., and Mann, M., Sci. Signal., 2010, vol. 3, ra3–ra3. doi 10.1126/scisignal.2000 475
Sharma, K., D’Souza, R.C.J., Tyanova, S., Schaab, C., Wisniewski, J.R., Cox, J., and Mann, M., Cell Rep., 2014, vol. 8, pp. 1583–1594. doi 10.1016/j.celrep. 2014.07.036
Mayya, V., Lundgren, D.H., Hwang, S.-I., Rezaul, K., Wu, L., Eng, J.K., Rodionov, V., and Han, D.K., Sci. Signal., 2009, vol. 2, ra46–ra46. doi 10.1126/scisignal.2000007
Grønborg, M., Kristiansen, T.Z., Stensballe, A., Andersen, J.S., Ohara, O., Mann, M., Jensen, O.N., and Pandey, A., Mol. Cell. Proteomics, 2002, vol. 1, pp. 517–527. doi 10.1074/MCP.M200010-MCP200
Kopylov, A.T. and Zgoda, V.G., Biomed. Khim., 2007, vol. 53, pp. 613–643.
Olsen, J.V., Blagoev, B., Gnad, F., Macek, B., Kumar, C., Mortensen, P., and Mann, M., Cell, 2006, vol. 127, pp. 635–648. doi 10.1016/j.cell.2006.09.026
Kondrat, R.W., McClusky, G.A., and Cooks, R.G., Anal. Chem., 1978, vol. 50, pp. 2017–2021. doi 10.1021/ac50036a020
Picotti, P. and Aebersold, R., Nat. Methods, 2012, vol. 9, pp. 555–566. doi 10.1038/nmeth.2015
Wolf-Yadlin, A., Hautaniemi, S., Lauffenburger, D.A., and White, F.M., Proc. Natl. Acad. Sci. USA, 2007, vol. 104, pp. 5860–5865. doi 10.1073/pnas.0608638104
Narumi, R., Murakami, T., Kuga, T, Adachi, J., Shiromizu, T., Muraoka, S., Kume, H., Kodera, Y., Matsumoto, M., Nakayama, K., Miyamoto, Y., Ishitobi, M., Inaji, H., Kato, K., and Tomonaga, T., J. Proteome Res., 2012, vol. 11, pp. 5311–5322. doi 10.1021/pr3005474
Yu, Y., Anjum, R., Kubota, K., Rush, J., Villen, J., and Gygi, S.P., Proc. Natl. Acad. Sci. USA, 2009, vol. 106, pp. 11606–11611. doi 10.1073/pnas.0905165106
Cuomo, A., Moretti, S., Minucci, S., and Bonaldi, T., Amino Acids, 2011, vol. 41, pp. 387–399. doi 10.1007/s00726-010-0668-2
Darwanto, A., Curtis, M.P., Schrag, M., Kirsch, W., Liu, P., Xu, G., Neidigh, J.W., and Zhang, K., J. Biol. Chem., 2010, vol. 285, pp. 21868–21876. doi 10.1074/jbc.M110.126813
LeRoy, G., DiMaggio, P.A., Chan, E.Y., Zee, B.M., Blanco, M., Bryant, B., Flaniken, I.Z., Liu, S., Kang, Y., Trojer, P., and Garcia, B.A., Epigenetics & Chromatin, 2013, vol. 6, p. 20. doi 10.1186/1756-8935-6-20
Jaffe, J.D., Wang, Y., Chan, H.M., Zhang, J., Huether, R., Kryukov, G.V, Bhang, H.C., Taylor, J.E., Hu, M., Englund, N.P., Yan, F., Wang, Z., Robert McDonald, E., Wei, L., Ma, J., Easton, J., Yu, Z., deBeaumount, R., Gibaja, V., Venkatesan, K., Schlegel, R., Sellers, W.R., Keen, N., Liu, J., Caponigro, G., Barretina, J., Cooke, V.G., Mullighan, C., Carr, S.A., Downing, J.R., Garraway, L.A., and Stegmeier, F., Nature Genetics, 2013, vol. 45, pp. 1386–1391. doi 10.1038/ng.2777
Shen, Z., Wang, B., Luo, J., Jiang, K., Zhang, H., Mustonen, H., Puolakkainen, P., Zhu, J., Ye, Y., and Wang, S., J. Proteomics, 2016, vol. 142, pp. 24–32. doi 10.1016/j.jprot.2016.05.002
Gao, J., Liao, R., Yu, Y., Zhai, H., Wang, Y., Sack, R., Peters, A.H.F.M., Chen, J., Wu, H., Huang, Z., Hu, M., Qi, W., Lu, C., Atadja, P., Oyang, C., Li, E., Yi, W., and Zhou, S., Anal. Chem., 2014, vol. 86, pp. 9679–9686. doi 10.1021/ac502333a
Udeshi, N.D., Svinkina, T., Mertins, P., Kuhn, E., Mani, D.R., Qiao, J.W., and Carr, S.A., Mol. Cell. Proteomics, 2013, vol. 12, pp. 825–831. doi 10.1074/mcp.O112.027094
Kim, W., Bennett, E.J., Huttlin, E.L., Guo, A., Li, J., Possemato, A., Sowa, M.E., Rad, R., Rush, J., Comb, M.J., Harper, J.W., and Gygi, S.P., Mol. Cell, 2011, vol. 44, pp. 325–340. doi 10.1016/j.molcel. 2011.08.025
Meierhofer, D., Wang, X., Huang, L., and Kaiser, P., J. Proteome Res., 2008, vol. 7, pp. 4566–4576. doi 10.1021/pr800 468j
Danielsen, J.M.R., Sylvestersen, K.B., Bekker-Jensen, S., Szklarczyk, D., Poulsen, J.W., Horn, H., Jensen, L.J., Mailand, N., and Nielsen, M.L., Mol. Cell. Proteomics, 2011, vol. 10, M110.003590-M110.003590. doi 10.1074/mcp.M110.003590
Wu, J., Qin, H., Li, T., Cheng, K., Dong, J., Tian, M., Chai, N., Guo, H., Li, J., You, X., Dong, M., Ye, M., Nie, Y., Zou, H., and Fan, D., Oncotarget, 2016, vol. 7, pp. 25315–25327. doi 10.18632/oncotarget.8287
Lattova, E., Bartusik, D., Spicer, V., Jellusova, J., Perreault, H., and Tomanek, B., Mol. Cell. Proteomics, 2011, vol. 10, no. 9, M111.007765–M111.007765. doi 10.1074/mcp.M111.007765
Pan, S., Brentnall, T.A., and Chen, R., W. J. Gastroenterol., 2016, vol. 22, p. 9288. doi 10.3748/wjg.v22.i42.9288
Fratta, E., Montico, B., Rizzo, A., Colizzi, F., Sigalotti, L., and Dolcetti, R., Oncotarget, 2016, vol. 7, pp. 57327–57350. doi 10.18632/oncotarget.10033
Varki, A., Kannagi, R., and Toole, B.P., Glycosylation Changes in Cancer. Essentials of Glycobiology, 2009.
Quin, R.J. and McGuckin, M.A., Int. J. Cancer, 2000, vol. 87, pp. 499–506. doi 10.1002/1097-0215(20000815)87:4<499::AID-IJC6>3.0.CO;2-9
Horm, T.M. and Schroeder, J.A., Cell Adh. Migr., 2013, vol. 7, pp. 187–198. doi 10.4161/cam.23131
DeNardo, B.D., Holloway, M.P., Ji, Q., Nguyen, K.T., Cheng, Y., Valentine, M.B., Salomon, A., and Altura, R.A., PLoS One, 2013, vol. 8. doi 10.1371/journal.pone.0082513
Ahmad, I., Iwata, T., and Leung, H.Y., Biochim. Biophys. Acta—Mol. Cell Res., 2012, vol. 1823, pp. 850–860. doi 10.1016/j.bbamcr.2012.01.004
Denduluri, S.K., Idowu, O., Wang, Z., Liao, Z., Yan, Z., Mohammed, M.K., Ye, J., Wei, Q., Wang, J., Zhao, L., and Luu, H.H., Genes Dis., 2015, vol. 2, pp. 13–25. doi 10.1016/j.gendis.2014.10.004
Cho, H.-S., Hayami, S., Toyokawa, G., Maejima, K., Yamane, Y., Suzuki, T., Dohmae, N., Kogure, M., Kang, D., Neal, D.E., Ponder, B.A.J., Yamaue, H., Nakamura, Y., and Hamamoto, R., Neoplasia, 2012, vol. 14, pp. 476–486.
Wu, X., Zahari, M.S., Renuse, S., Nirujogi, R.S., Kim, M.S., Manda, S.S., Stearns, V., Gabrielson, E., Sukumar, S., and Pandey, A., Mol. Cell Proteomics, 2015, vol. 14, pp. 2887–2900. doi 10.1074/mcp.M115.050484
Gao, Z., Zhang, J., Bi, M., Han, X., Han, Z., Wang, H., and Ou, Y., Int. J. Clin. Exp. Pathol., 2015, vol. 8, pp. 4791–4798.
Hoshino, R., Chatani, Y., Yamori, T., Tsuruo, T., Oka, H., Yoshida, O., Shimada, Y., Ari-i, S., Wada, H., Fujimoto, J., and Kohno, M., Oncogene, 1999, vol. 18, pp. 813–822. doi 10.1038/sj.onc.1202367
Baranski, Z., Booij, T.H., Kuijjer, M.L., Jong, Y., Cleton-Jansen, A.-M., Price, L.S., van de Water, B, Bovée, J.V.M.G., Hogendoorn, P.C.W., Danen, E.H.J., Genes Cancer, 2015, November:503. doi 10.18632/genesandcancer.91
Dai, C. and Gu, W., Trends Mol. Med., 2010, vol. 16, pp. 528–536. doi 10.1016/j.molmed.2010.09.002
Knudsen, E.S. and Knudsen, K.E., Nat. Rev. Cancer, 2008, vol. 8, pp. 714–724. doi 10.1038/nrc2401
Lin, P.-C., Yang, Y.-F., Tyan, Y.-C., Hsiao, E.S.L., Chu, P.-C., Lee, C.-T., Lee, J.-C., Chen, Y.-M.A., and Liao, P.-C., PLoS One, 2016, vol. 11. doi 10.1371/journal.pone.0158844
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Original Russian Text © M.G. Zavialova, V.G. Zgoda, E.N. Nikolaev, 2017, published in Biomeditsinskaya Khimiya.
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Zavialova, M.G., Zgoda, V.G. & Nikolaev, E.N. Analysis of the role of protein phosphorylation in the development of diseases. Biochem. Moscow Suppl. Ser. B 11, 203–218 (2017). https://doi.org/10.1134/S1990750817030118
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DOI: https://doi.org/10.1134/S1990750817030118