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Self-association behavior of an amphiphilic drug nortriptyline hydrochloride under the influence of inorganic salts

  • Chemical Physics of Biological Processes
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Abstract

Herein, the micellization phenomena of an amphiphilic antidepressant drug nortriptyline hydrochloride (NOT) have been studied using tensiometric technique in the absence and presence of different concentration of inorganic salts (NaCl, NaBr and KCl) at 298.15 K. NOT is employed for the relief of symptoms of depression. In presence of inorganic salt the CMC value decreases which is explained on the basis of nature and ion size. Various parameters, i.e., the maximum surface excess concentration at the air/solution interface (Γmax), minimum area per head group at the air/solution interface (Amin), free energy of micellization (ΔG m o), minimum energy of surface (G min) and standard Gibbs energy of adsorption (ΔG ads o) were evaluated and discussed in detail.

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References

  1. D. Attwood and A. T. Florence, Surfactant Systems: Their Chemistry, Pharmacy and Biology (Chapman and Hall, New York, 1983).

    Book  Google Scholar 

  2. D. Kumar and M. A. Rub, Tenside Surfactants, Deterg. 52, 464 (2015).

    Article  CAS  Google Scholar 

  3. M. A. Rub, F. Khan, D. Kumar, and A. M. Asiri, Tenside Surfactants, Deterg. 52, 236 (2015).

    Article  Google Scholar 

  4. S. Schreier, S. V. P. Malheiros, and E. de Paula, Biochim. Biophys. Acta 1508, 201 (2000).

    Google Scholar 

  5. M. A. Rub, N. Azum, F. Khan, A. G. Al-Sehemi, and A. M. Asiri, Korean J. Chem. Eng. 32, 2142 (2015).

    Article  Google Scholar 

  6. M. A. Rub, A. M. Asiri, N. Azum, and Kabir-ud-Din, J. Ind. Eng. Chem. 20, 2023 (2014).

    Article  CAS  Google Scholar 

  7. D. Attwood and R. Natarajan, J. Pharm. Pharmacol. 33, 136 (1981).

    Article  CAS  Google Scholar 

  8. D. Attwood, Adv. Colloid Interface Sci. 55, 271 (1995).

    Article  CAS  Google Scholar 

  9. E. J. Kim and D. O. Shah, Langmuir 18, 10105 (2002).

    Article  CAS  Google Scholar 

  10. P. Taboada, D. Attwood, J. M. Ruso, M. Garcia, and V. Mosquera, Phys. Chem. Chem. Phys. 2, 5175 (2000).

    Article  CAS  Google Scholar 

  11. P. Taboada, D. Attwood, J. M. Ruso, M. Gracia, and V. Mosquera, Langmuir 17, 173 (2001).

    Article  CAS  Google Scholar 

  12. M. J. Rosen, Surfactants and Interfacial Phenomena, 3rd ed. (Wiley, New York, 2004).

    Book  Google Scholar 

  13. Surfactants: A Practical Handbook, Ed. by K. R. Lange (Hanser, Münich, 1999).

  14. D. Kumar and M. A. Rub, J. Phys. Org. Chem. 29, 394 (2016).

    Article  CAS  Google Scholar 

  15. M. A. Rub, N. Azum, and A. M. Asiri, J. Mol. Liq. 218, 595 (2016).

    Article  Google Scholar 

  16. J. N. Israelachvili, Intermolecular and Surface Force (Academic, New York, 1992).

    Google Scholar 

  17. L. Zang, P. Somasundaran, and C. Maltesh, Langmuir 12, 2371 (1996).

    Article  Google Scholar 

  18. S. Kumar, and A. Z. Naqvi, Langmuir 17, 4787 (2001).

    Article  CAS  Google Scholar 

  19. M. A. Rub, A. M. Asiri, J. M. Khan, et al., J. Taiwan Inst. Chem. Eng. 45, 2068 (2014).

    Article  CAS  Google Scholar 

  20. E. Junquera, J. C. Romero, and E. Aicart, Langmuir 17, 1826 (2001).

    Article  CAS  Google Scholar 

  21. F. Khan, M. A. Rub, N. Azum, D. Kumar, and A.M. Asiri, J. Solution Chem. 44, 1937 (2015).

    Article  CAS  Google Scholar 

  22. M. A. Rub, A. M. Asiri, N. Azum, et al., Thermochim. Acta 574, 26 (2013).

    Article  CAS  Google Scholar 

  23. F. Khan, D. Kumar, N. Azum, M. A. Rub, and A.M. Asiri, J. Mol. Liq. 208, 84 (2015).

    Article  CAS  Google Scholar 

  24. Y. Marcus, Ion Solvation (Wiley Interscience, Brisbane, Toronto, Singapore, Chichester, New York, 1985).

    Google Scholar 

  25. A. Gonzalez-Perez, J. L. del Castillo, J. Czapkiewicz, and J. R. Rodriguez, J. Phys. Chem. B 105, 1720 (2001).

    Article  CAS  Google Scholar 

  26. J. R. Rodriguez, A. Gonzalez-Perez, J. L. del Castillo, and J. Czapkiewicz, J. Colloid Interface Sci. 250, 438 (2002).

    Article  CAS  Google Scholar 

  27. B. V. Zhmud, F. Tiberg, and J. Kizling, Langmuir 16, 2557 (2000).

    Article  CAS  Google Scholar 

  28. Q. Zhou and M. J. Rosen, Langmuir 19, 4555 (2003).

    Article  CAS  Google Scholar 

  29. N. Azum, M. A. Rub, and A. M. Asiri, Colloids Surf. B 121, 158 (2014).

    Article  CAS  Google Scholar 

  30. V. Taboada, P. Martinez-Landeira, J. M. Ruso, M. Garcia, and V. Mosquera, Colloids Surf. A 197, 95 (2002).

    Article  CAS  Google Scholar 

  31. M. K. Al-Muhanna, M. A. Rub, N. Azum, S. B. Khan, and A. M. Asiri, J. Chem. Thermodyn. 89, 112 (2015).

    Article  CAS  Google Scholar 

  32. A. Z. Naqvi, M. A. Rub, Colloid J. 77, 525 (2015).

    Article  CAS  Google Scholar 

  33. Kabir-ud-Din, M. A. Rub, and A. Z. Naqvi, J. Solution Chem. 44, 2448 (2015).

  34. M. A. Rub, F. Khan, N. Azum, A. M. Asiri, and H. M. Marwani, J. Taiwan Inst. Chem. Eng. 60, 32 (2016).

    Article  Google Scholar 

  35. M. J. Rosen and S. Aronson, Colloids Surf. 3, 201 (1981).

    Article  CAS  Google Scholar 

  36. N. Azum, M. A. Rub, and A. M. Asiri, J. Mol. Liq. 216, 94 (2016).

    Article  CAS  Google Scholar 

  37. G. Sugihara, A. M. Miyazono, S. Nagadome, et al., J. Oleo Sci. 52, 449 (2003).

    Article  CAS  Google Scholar 

  38. N. Azum, M. A. Rub, and A. M. Asiri, J. Mol. Liq. 196, 14 (2014).

    Article  CAS  Google Scholar 

  39. F. Khan, U. S. Siddiqui, M. A. Rub, I. A. Khan, and Kabir-ud-Din, J. Mol. Liq. 191, 29 (2014).

    Article  CAS  Google Scholar 

  40. F. Khan, U. S. Siddiqui, M. A. Rub, I. A. Khan, and Kabir-ud-Din, J. Dispersion Sci. Technol. 36, 83 (2015).

    Article  CAS  Google Scholar 

  41. M. A. Rub, F. Khan, M. S. Sheikh, N. Azum, and A.M. Asiri, J. Chem. Thermodyn. 96, 196 (2016).

    Article  Google Scholar 

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Malik Abdul Rub, Naved Azum & Abdullah M. Asiri

  2. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Malik Abdul Rub, Naved Azum & Abdullah M. Asiri

Authors
  1. Malik Abdul Rub
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  2. Naved Azum
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  3. Abdullah M. Asiri
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Correspondence to Malik Abdul Rub.

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Rub, M.A., Azum, N. & Asiri, A.M. Self-association behavior of an amphiphilic drug nortriptyline hydrochloride under the influence of inorganic salts. Russ. J. Phys. Chem. B 10, 1007–1013 (2016). https://doi.org/10.1134/S1990793116060257

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  • DOI: https://doi.org/10.1134/S1990793116060257

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