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The Role of Sestrins in the Regulation of the Cellular Response to Stress

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Abstract

This review is devoted to the analysis of proteins of the sestrin family and their role in the response of cells to stress. The paper describes the structure and functions of sestrins and their key role in the regulation of mTOR kinase and metabolism. In addition, the functions of sestrins in the regulation of aging and age-related diseases are considered in detail in this review.

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ACKNOWLEDGMENTS

The author thanks P.M. Chumakov for long-term cooperation and assistance in the work.

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  1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    A. V. Budanov

  2. Trinity College, Dublin, Ireland

    A. V. Budanov

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Budanov, A.V. The Role of Sestrins in the Regulation of the Cellular Response to Stress. Biol Bull Rev 12, 347–364 (2022). https://doi.org/10.1134/S2079086422040028

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