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The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats

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Abstract

Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 10, Novosibirsk, 630090, Russia

    V. V. Bulygina, P. N. Men’shanov, D. A. Lanshakov & N. N. Dygalo

  2. Novosibirsk National Research State University, ul. Pirogova 2, Novosibirsk, 630090, Russia

    D. A. Lanshakov & N. N. Dygalo

Authors
  1. V. V. Bulygina
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  2. P. N. Men’shanov
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  3. D. A. Lanshakov
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  4. N. N. Dygalo
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Correspondence to V. V. Bulygina.

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Original Russian Text © V.V. Bulygina, P.N. Men’shanov, D.A. Lanshakov, N.N. Dygalo, 2014, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2014, No. 6, pp. 616–620.

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Bulygina, V.V., Men’shanov, P.N., Lanshakov, D.A. et al. The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats. Biol Bull Russ Acad Sci 41, 540–544 (2014). https://doi.org/10.1134/S1062359014060028

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  • DOI: https://doi.org/10.1134/S1062359014060028

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