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Synthesis, Phosphonylation, and Anti-Viral Activity of Some 6-Aryl-5-cyano-2-thiouracils

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Abstract

A series of 6-aryl-5-cyano-2-thiouracils was synthesized, the reaction of which with diethyl chloroethynylphosphonate leads to the selective formation of new 3-phosphonylated thiazolo[3,2-a]pyrimidines. For the starting 6-aryl-5-cyano-2-thiouracils and their phosphonylated derivatives, antiviral activity against influenza A (H1N1) virus and cytotoxicity were studied.

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Funding

This work was financially supported by the Ministry of Science and Higher Education (project no. 785.00.X6019) Russian Foundation for Basic Research (grant no. 19-03-00365) using the equipment of the Engineering Center of the St. Petersburg State Institute of Technology and the Resource Center “Chemical Analysis and Materials Research Center” of St. Petersburg State University.

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Authors and Affiliations

  1. St. Petersburg State University, 199034, St. Petersburg, Russia

    A. A. Babushkina

  2. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    Yu. L. Piterskaya & D. M. Egorov

  3. A.A. Smorodintsev Research Institute of Influenza, 197376, St. Petersburg, Russia

    A. A. Shtro, Yu. V. Nikolaeva, A. V. Galochkina & A. M. Klabukov

Authors
  1. A. A. Babushkina
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  2. Yu. L. Piterskaya
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  3. A. A. Shtro
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  4. Yu. V. Nikolaeva
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  5. A. V. Galochkina
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  6. A. M. Klabukov
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  7. D. M. Egorov
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Correspondence to D. M. Egorov.

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Babushkina, A.A., Piterskaya, Y.L., Shtro, A.A. et al. Synthesis, Phosphonylation, and Anti-Viral Activity of Some 6-Aryl-5-cyano-2-thiouracils. Russ J Gen Chem 92, 18–23 (2022). https://doi.org/10.1134/S1070363222010042

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  • DOI: https://doi.org/10.1134/S1070363222010042

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