Methods of hysterectomy: systematic review and meta-analysis of randomised controlled trials
BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7506.1478 (Published 23 June 2005) Cite this as: BMJ 2005;330:1478
- Neil Johnson, associate professor (n.johnson{at}auckland.ac.nz)11,
- David Barlow, head of department2,
- Anne Lethaby, biostatistician1,
- Emma Tavender, collaborative review group coordinator3,
- Liz Curr, registrar in obstetrics and gynaecology1,
- Ray Garry, professor of obstetrics and gynaecology4
- 1 University of Auckland, National Women's Department of Obstetrics and Gynaecology, Auckland Hospital, Auckland, New Zealand
- 2 Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU
- 3 Cochrane Oral Health Group, University of Manchester, Manchester
- 4 University of Western Australia Department of Obstetrics and Gynaecology, Perth, Australia
- Correspondence to: N Johnson
- Accepted 9 May 2005
Abstract
Objective To evaluate the most appropriate surgical method of hysterectomy (abdominal, vaginal, or laparoscopic) for women with benign disease.
Design Systematic review and meta-analysis.
Data sources Cochrane Menstrual Disorders and Subfertility Group Trials Register, Cochrane Central Register of Controlled Trials, Medline, Embase, and Biological Abstracts.
Selection of studies Only randomised controlled trials were selected; participants had to have benign gynaecological disease; interventions had to comprise at least one hysterectomy method compared with another; and trials had to report primary outcomes (time taken to return to normal activities, intraoperative visceral injury, and major long term complications) or secondary outcomes (operating time, other immediate complications of surgery, short term complications, and duration of hospital stay).
Results 27 trials (total of 3643 participants) were included. Return to normal activities was quicker after vaginal than after abdominal hysterectomy (weighted mean difference 9.5 (95% confidence interval 6.4 to 12.6) days) and after laparoscopic than after abdominal hysterectomy (difference 13.6 (11.8 to 15.4) days), but was not significantly different for laparoscopic versus vaginal hysterectomy (difference −1.1 (−4.2 to 2.1) days). There were more urinary tract injuries with laparoscopic than with abdominal hysterectomy (odds ratio 2.61 (95% confidence interval 1.22 to 5.60)), but no other intraoperative visceral injuries showed a significant difference between surgical approaches. Data were notably absent for many important long term patient outcome measures, where the analyses were underpowered to detect important differences, or they were simply not reported in trials.
Conclusions Significantly speedier return to normal activities and other improved secondary outcomes (shorter duration of hospital stay and fewer unspecified infections or febrile episodes) suggest that vaginal hysterectomy is preferable to abdominal hysterectomy where possible. Where vaginal hysterectomy is not possible, laparoscopic hysterectomy is preferable to abdominal hysterectomy, although it brings a higher chance of bladder or ureter injury.
Introduction
Three main types of hysterectomy are now used—abdominal, vaginal, and laparoscopic. Traditionally, abdominal hysterectomy has been used for gynaecological malignancy—when other pelvic disease is present, such as endometriosis or adhesions—or if the uterus is enlarged. It remains the “fallback option” if the uterus cannot be removed by another approach.
Vaginal hysterectomy was originally used only for prolapse, but it is now also used for menstrual abnormalities when the uterus is of fairly normal size. Vaginal hysterectomy is regarded as less invasive than abdominal hysterectomy.
In laparoscopic hysterectomy, at least part of the operation is done laparoscopically1; this method requires greater surgical expertise than the vaginal and abdominal methods. The proportion of hysterectomies performed laparoscopically has gradually increased, and, although the procedure takes longer, proponents have emphasised several advantages: the opportunity to diagnose and treat other pelvic diseases (such as endometriosis) and to carry out adnexal surgery including the removal of the ovaries; the ability to secure thorough intraperitoneal haemostasis at the end of the procedure; and a rapid recovery time.2
Three subcategories of laparoscopic hysterectomy have been described.3 In laparoscopic assisted vaginal hysterectomy (LAVH), the procedure is done partly laparoscopically and partly vaginally, but the laparoscopic component does not involve uterine vessel ligation. In uterine vessel ligation laparoscopic hysterectomy (LH(a)), although the uterine vessels are ligated laparoscopically, part of the operation is done vaginally. In total laparoscopic hysterectomy, the entire operation (including suturing of the vaginal vault) is done laparoscopically. This method of laparoscopic hysterectomy requires the highest degree of surgical skill and is currently done only by a very small proportion of gynaecologists. It has been unclear whether total laparoscopic hysterectomy offers benefits over other forms of hysterectomy.
We subcategorised laparoscopic hysterectomy because surgeons using these methods need evidence based information about the particular procedure that they use.
The introduction of laparoscopic approaches in hysterectomies has prompted a much greater interest in the proper scientific evaluation of all forms of hysterectomy. This review aims to assess the most beneficial and least harmful surgical method.
Methods
In March 2004 we searched the Cochrane Menstrual Disorders and Subfertility Group Trials Register, the Cochrane Central Register of Controlled Trials, Medline, Embase, and Biological Abstracts. We performed data extraction and quantitative data synthesis according to the Cochrane Menstrual Disorders and Subfertility Group's guidelines.4 We selected trials according to the following eligibility criteria: we selected only randomised controlled trials; participants had to have benign gynaecological disease; interventions had to comprise at least one surgical approach to hysterectomy compared with another (excluding subtotal hysterectomy); and trials had to report primary outcomes (time it took participants to return to normal activities, intraoperative visceral injury, and major long term complications) or secondary outcomes (operating time, other immediate complications of surgery, short term complications, and duration of hospital stay).
We performed sensitivity analyses to examine the stability of the results in relation to “surgeon effect” and subcategorisation of laparoscopic hysterectomy.
Results
Trial flow
We identified 42 trials, of which we included 275–31 (table 1) and excluded 1032–41 (with reasons for exclusion outlined in the longer version of this article, published as a Cochrane review4); the five remaining studies await assessment.42–46 We contacted the first authors of nine published abstracts to extract details that had not been reported: five studies were subsequently published, of which two were included6 18 and three excluded37 39 40; four replies have not yet been received42 43 45 46; and a further study, in Swedish, awaits translation.44
Quality of studies included in meta-analysis
Of the 27 included trials (with a total of 3643 participants), two compared vaginal with abdominal hysterectomy,5 18 16 compared laparoscopic with abdominal hysterectomy,7–9 11 13 14 16 17 19 22 24–26 29–31 four compared laparoscopic with vaginal hysterectomy,6 23 27 28 one compared LAVH with LH(a),15 one compared laparoscopic with abdominal and vaginal hysterectomy,10 and three compared laparoscopic, vaginal, and abdominal hysterectomy.12 20 21
Study characteristics and validity assessment
Quality criteria, presented in detail elsewhere,4 are summarised in table 1. The possibility that trial authors might have selectively reported “interesting” results potentially jeopardises the reliability of conclusions both from the individual studies and from this review.
We used Richardson's classification23 to categorise 22 of the 25 included studies that involved laparoscopic hysterectomy according to the amount of laparoscopic content (table 2). We also subcategorised these 22 trials as either LAVH, LH(a) or total, depending on the extent of the surgery performed laparoscopically and vaginally (table 1).
Richardson staging of laparoscopic hysterectomy (22 trials)
Meta-analysis results
All meta-analysis graphs, with summary statistics and 95% confidence intervals for all comparisons and outcomes, are published electronically in the Cochrane Library.4
Primary outcomes
Return to normal activities—The meta-analysis in figure 1 shows that patients returned to normal activities sooner after vaginal than after abdominal hysterectomy (weighted mean difference 12.3 (95% confidence interval 4.8 to 19.9) days); although statistical heterogeneity was present for this outcome (P value 0.02, χ2 test; I2 = 75.3%), similar results were obtained with both fixed and random effects models. Return to normal activities was also quicker after laparoscopic than after abdominal hysterectomy (difference 13.3 (9.9 to 16.8) days); although statistical heterogeneity was present (P value 0.004, χ2 test; I2 = 71.2%), similar results were obtained using both fixed and random effects models. We found no significant difference between laparoscopic and vaginal hysterectomy in return to normal activities (−1.1 (−4.2 to 2.1) days).
Meta-analysis of return to normal activities (number of days). Statistical pooling used random effects statistical model for vaginal versus abdominal hysterectomy and for laparoscopic versus abdominal hysterectomy, and fixed effects statistical model for laparoscopic versus vaginal hysterectomy. AH=abdominal hysterectomy; VH=vaginal hysterectomy; LH=laparoscopic hysterectomy; LAVH=laparoscopic assisted vaginal hysterectomy; LH(a)=laparoscopic hysterectomy where laparoscopic procedures include uterine artery ligation; TLH=total laparoscopic hysterectomy
Intraoperative visceral injury—Where bladder and ureter injuries were pooled as “urinary tract injury” (figure 2), we found a significant increase in urinary tract injury for laparoscopic versus abdominal hysterectomy (odds ratio 2.61 (95% confidence interval 1.22 to 5.60)) but no significant differences in urinary tract injury for laparoscopic versus vaginal hysterectomy (1.00 (0.36 to 2.75)) or for LH(a) versus LAVH (1.60 (0.29 to 7.83)). No other intraoperative visceral injuries (including bladder and ureter considered independently, and bowel and vascular injury) showed a significant difference between surgical approaches.
Meta-analysis of urinary tract (bladder or ureter) injury. Statistical pooling used fixed effects statistical model (no statistical heterogeneity present). AH=abdominal hysterectomy; VH=vaginal hysterectomy; LH=laparoscopic hysterectomy; LAVH=laparoscopic assisted vaginal hysterectomy; LH(a)=laparoscopic hysterectomy where laparoscopic procedures include uterine artery ligation; TLH=total laparoscopic hysterectomy
Major long term complications—We found no significant differences in fistula formation, urinary dysfunction, sexual dysfunction, or patient satisfaction when we compared surgical approaches, although for most of these outcomes the analyses were underpowered to detect important differences. Data were notably not reported in trials for many important long term outcome measures, including chronic pelvic or abdominal pain, bowel dysfunction, and vaginal prolapse.
Secondary outcomes
Operation time—Both trials in the meta-analysis of vaginal versus abdominal hysterectomy showed a significant difference in the length of time of the operation, but in opposite directions. Abdominal hysterectomies were performed significantly faster than laparoscopic hysterectomies (weighted mean difference 18.0 (95% confidence interval 1.0 to 35.1) minutes), although this difference was not apparent in trials where the subcategory LAVH was compared with abdominal hysterectomy. Statistical heterogeneity was present for operation time for laparoscopic versus abdominal hysterectomy (P value < 0.0001, χ2 test; I2 = 96.2%), but similar results were obtained with fixed and random effects models, except for a significantly shorter operation time for the LAVH subcategory versus abdominal hysterectomy, apparent with a fixed effects model (difference 7.6 (3.0 to 12.2) minutes). Vaginal hysterectomy also had a shorter operation time than laparoscopic hysterectomy (difference 44.5 (26.2 to 62.8) minutes), and, although statistical heterogeneity was present (P value 0.001, χ2 test; I2 = 80.6%), similar results were obtained with fixed and random effects models. LAVH had a significantly shorter operation time than LH(a) (difference 25.3 (10.0 to 40.6) minutes).
Other intraoperative complications—The number of women with substantial bleeding and the incidence of unintended laparotomy (where abdominal hysterectomy was not one of the treatment comparisons) did not differ significantly between surgical approaches.
Short term outcomes and complications—Hospital stay was significantly shorter for women who had had vaginal rather than abdominal hysterectomy (weighted mean difference 1.0 (0.7 to 1.2) days) or laparoscopic rather than abdominal hysterectomy (difference 2.0 (1.9 to 2.2) days); statistical heterogeneity was present (P value < 0.0001, χ2 test; I2 = 95.0%), but similar results were obtained with a random effects model. Duration of hospital stay was not significantly different for laparoscopic versus vaginal hysterectomy or for LH(a) versus LAVH. For vaginal versus abdominal hysterectomy, there were significantly fewer unspecified infections or febrile episodes (odds ratio 0.42 (95% confidence interval 0.21 to 0.83)). For laparoscopic versus abdominal hysterectomy, there were significantly fewer wound or abdominal wall infections (0.32 (0.12 to 0.85)) and significantly fewer unspecified infections or febrile episodes (0.65 (0.49 to 0.87)). There were no significant differences between surgical approaches in the need for blood transfusion, although laparoscopic hysterectomy was associated with a significantly lower mean blood loss than abdominal hysterectomy (weighted mean difference 45.3 ml (95% confidence interval 17.9 ml to 72.7 ml)) and a smaller drop in haemoglobin (0.55 g/l (0.28 g/l to 0.82 g/l)). We found no evidence of a significant difference between surgical approaches for occurrence of pelvic haematoma, vaginal cuff infection, urinary tract infection, chest infection, or thromboembolic events.
Sensitivity analyses
Exclusion of the three trials in which surgeons for one intervention were unequivocally different from those performing the other intervention14 19 22 did not alter the significance of any meta-analysis results.
When laparoscopic hysterectomy was subcategorised, the longer operating time compared with abdominal hysterectomy was not apparent for LAVH. All other subcategory meta-analyses of laparoscopic versus abdominal hysterectomy and laparoscopic versus vaginal hysterectomy showed results that were similar to the respective meta-analysis of laparoscopic hysterectomy as a pooled group.
Data not included in meta-analysis
Data expressed as medians were not included in the meta-analysis, and these results are presented in full elsewhere.4 These data showed consistently lower postoperative pain scores for laparoscopic than abdominal hysterectomy, in addition to improved quality of life, body image scores; and increased sexual frequency at six weeks, but these differences disappeared by one year.10 Mean total hospital cost was significantly higher for laparoscopic than vaginal hysterectomy.28
Discussion
Our data suggest that vaginal hysterectomy is preferable to abdominal hysterectomy, provided that it can be done safely. Claims that laparoscopic hysterectomy can allow identification of pelvic disease that might otherwise lead to complications during vaginal hysterectomy and that the meticulous haemostasis achievable during laparoscopic hysterectomy might reduce pelvic haematomas or vaginal cuff infections have not been borne out in this review. However, a laparoscopic approach may be appropriate if an oophorectomy is needed. Whether the increased detection of unexpected disease at laparoscopic hysterectomy (compared with vaginal hysterectomy)10 affects subsequent clinical outcomes remains uncertain.
Operating time
Operating time is longer for laparoscopic than for both abdominal and vaginal hysterectomy. However, LAVH had a significantly shorter operating time than abdominal hysterectomy, and LAVH had a significantly shorter mean operating time than LH(a), the latter being the lengthiest operation.
Urinary tract injury
The increased incidence of urinary tract injury (bladder and ureter injuries pooled as a single category) from laparoscopic hysterectomy seen in our review supports that reported elsewhere in non-randomised studies.10 47 48 However, our study was not powerful enough to detect an increase in ureteric injury considered independently (that occurred in 1 in 78 women having laparoscopic hysterectomy and 1 in 492 women having abdominal hysterectomy). Urinary tract damage, in particular ureteric injury, remains the major concern in relation to the laparoscopic approach. Furthermore, in the largest randomised controlled trial included in this review10 the authors pooled cases in which at least one major complication occurred and found a significant increase in this outcome for laparoscopic versus abdominal hysterectomy (but not laparoscopic versus vaginal hysterectomy). Although it could be speculated that laparoscopic uterine artery ligation is the manoeuvre most likely to increase the risk of ureteric injury, especially if the surgeon is unskilled in such a procedure, we were unable to confirm this as trials of LAVH versus abdominal hysterectomy did not report on ureteric injury.
Methodological challenges and surgical training
It is particularly difficult to assess validity of methodologies used in systematic reviews where surgical rather than medical interventions are tested—complicated by variable expertise among surgeons and the learning process. This is well illustrated by heterogeneity in such outcomes as operating time, even when the “traditional” vaginal and abdominal hysterectomy techniques are compared (some surgeons are better trained in vaginal hysterectomy, and some in abdominal hysterectomy).
What is already known on this topic
Abdominal hysterectomy has been regarded as the most invasive approach to hysterectomy for women with benign disease
Laparoscopic hysterectomy requires greater surgical expertise
Previous reviews have reached different conclusions about the relative merits of laparoscopic, abdominal, and vaginal hysterectomy
What this study adds
Important gaps in outcome data have been highlighted, especially for long term outcomes
No outcomes are significantly worse for vaginal hysterectomy than for any other method of hysterectomy—vaginal is preferable to abdominal hysterectomy where possible
No evidence supports the use of laparoscopic hysterectomy rather than vaginal hysterectomy if the latter can be done safely
Compared with abdominal hysterectomy, laparoscopic hysterectomy is associated with less blood loss, shorter hospital stay, speedier return to normal activities, and fewer abdominal wall infections or febrile episodes, but it takes longer and urinary tract injuries are more likely
The method of hysterectomy in any given case will inevitably differ among gynaecologists. Until the past few years, the vast majority of hysterectomies for benign disease were still performed abdominally,3 and this is likely still to be the case in most settings.49 Although many gynaecologists in training are now exposed to laparoscopic hysterectomy, very few newly trained gynaecologists will have sufficient expertise and confidence to tackle total laparoscopic hysterectomy, which requires the highest level skills. More surgeons will be trained to do LAVH (and indeed some gynaecologists who have not received specific training have acquired the skills to perform LAVH and LH(a)). Although it has been suggested that LAVH does little more than combine the complications of laparoscopic surgery with those of vaginal surgery,3 this has not been supported in our review.
One important benefit of the introduction of LAVH and LH(a) into gynaecology training has been to increase surgeons' confidence and skill with vaginal surgery, thus making vaginal hysterectomy a more feasible option for many.
Conclusions
Our conclusions are limited by the strength of the evidence: for many outcomes, including many important long term outcomes, data were notably absent. Our review found no important disadvantages of vaginal hysterectomy compared with any other surgical approach, thus it remains an excellent option. Avoiding abdominal hysterectomy accelerates recovery, diminishes postoperative pain, and avoids abdominal wall infections and general postoperative febrile illness. Laparoscopic hysterectomy may help to avoid a laparotomy, but urinary tract injury is a genuine concern. Research is needed to ascertain longer term outcomes and to evaluate the newer approaches to hysterectomy, such as total laparoscopic hysterectomy.
Acknowledgments
We thank staff at the editorial base of the Cochrane Menstrual Disorders and Subfertility Group in Auckland, especially Cindy Farquhar and Michelle Proctor.
Footnotes
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Contributors NJ, DB, AL, and RG jointly conceived the idea for the study. NJ helped to design the study, wrote the protocol, helped to select trials for inclusion and do the data extraction, conducted the analyses, and wrote the final manuscript. He is also the guarantor for the paper. DB helped to design the study and commented on the protocol and the final manuscript. AL helped to design the study, commented on the protocol, helped with the selection of trials for inclusion, with data extraction, and with the analyses, and commented on the final manuscript. ET and LC helped with the selection of trials for inclusion, with data extraction, and with the analyses, and commented on the final manuscript. RG helped to design the study and commented on the protocol and the final manuscript.
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Competing interests RG is the principal investigator in a United Kingdom based multicentre randomised trial comparing laparoscopic hysterectomy with both abdominal and vaginal hysterectomy.
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Ethical approval Not needed.