A Novel Cytotoxic Prenylated Flavonoid from the Root of Morus alba

Kofujita Hisayoshi; Yaguchi Masashi; Doi Norio; Suzuki Koichi

doi:10.11416/jibs.73.113

Journal of Insect Biotechnology and Sericology

Online ISSN : 1884-7978
Print ISSN : 1346-8073
ISSN-L : 1346-8073

Regular Articles

A Novel Cytotoxic Prenylated Flavonoid from the Root of Morus alba

Kofujita Hisayoshi, Yaguchi Masashi, Doi Norio, Suzuki Koichi

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Keywords: Novel prenylated flavanone, Morus alba, root, cytotoxic activity

JOURNAL FREE ACCESS

2004 Volume 73 Issue 3 Pages 113-116

DOI https://doi.org/10.11416/jibs.73.113

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Abstract

A novel prenylated flavanone was isolated from ethyl acetate extracts of the hard-wood cutting root of Kinuyutaka, a cultivar of Morus alba. The structure, 7, 2', 4', 6'-tetrahydoroxy-6-geranylflavanone, was revealed by spectral analyses. This prenylated flavanone exhibited cytotoxic activity against rat hepatoma (dRLh84) cells with an IC₅₀ of 52.8μg/ml.

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