Shawn M. Douglas
ABSTRACT
We have developed a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures [Douglas, Dietz, et al. 2009]. Previously, scaffolded DNA origami has been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome [Rothemund 2006]. Now we have succeeded in building custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. Successful extension from two dimensions to three dimensions in this way depended critically on calibration of folding conditions. A general capability for building complex, three-dimensional nanostructures will be of great interest to biologists, chemists, physicists, engineers, and computer scientists.
Supplemental Material
- Dietz, H., Douglas, S. M., Shih, W. M. 2009. Folding DNA into twisted and curved nanoscale shapes. Science. In review.Google Scholar
- Douglas, S. M., Dietz H., Liedl, T., Högberg, B., Graf, F., Shih, W. M. 2009. Self assembly of DNA into three-dimensional nanoscale shapes. Nature, 459, 414--418.Google ScholarCross Ref
- Douglas, S. M., Marblestone, A. M., Teerapittayanon, S., Vazquez, A., Church, G. M., Shih, W. M. 2009. Rapid prototyping of three-dimensional DNA-origami shapes with caDNAno. Nucleic Acids Res. In press.Google Scholar
- Rothemund, P. W. K. 2006. Folding DNA to create nanoscale shapes and patterns. Nature, 440, 297--302.Google ScholarCross Ref
Index Terms
- Design and self-assembly of DNA into nanoscale 3D shapes
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